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dc.contributor.authorDeng, Lin
dc.contributor.authorWang, Guangchao
dc.contributor.authorRen, Jian
dc.contributor.authorZhang, Bei
dc.contributor.authorYan, Jingjing
dc.contributor.authorLi, Wengang
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2015-08-03T09:43:10Z
dc.date.available2015-08-03T09:43:10Z
dc.date.issued2012
dc.identifier.citationDeng, L., Wang, G., Ren, J., Zhang, B., Yan, J., Li, W., & Khashab, N. M. (2012). Enzymatically triggered multifunctional delivery system based on hyaluronic acid micelles. RSC Advances, 2(33), 12909. doi:10.1039/c2ra21888g
dc.identifier.issn20462069
dc.identifier.doi10.1039/c2ra21888g
dc.identifier.urihttp://hdl.handle.net/10754/562029
dc.description.abstractTumor targetability and stimuli responsivity of drug delivery systems (DDS) are key factors in cancer therapy. Implementation of multifunctional DDS can afford targetability and responsivity at the same time. Herein, cholesterol molecules (Ch) were coupled to hyaluronic acid (HA) backbones to afford amphiphilic conjugates that can self-assemble into stable micelles. Doxorubicin (DOX), an anticancer drug, and superparamagnetic iron oxide (SPIO) nanoparticles (NPs), magnetic resonance imaging (MRI) contrast agents, were encapsulated by Ch-HA micelles and were selectively released in the presence of hyaluronidase (Hyals) enzyme. Cytotoxicity and cell uptake studies were done using three cancer cell lines (HeLa, HepG2 and MCF7) and one normal cell line (WI38). Higher Ch-HA micelles uptake was seen in cancer cells versus normal cells. Consequently, DOX release was elevated in cancer cells causing higher cytotoxicity and enhanced cell death. © 2012 The Royal Society of Chemistry.
dc.publisherRoyal Society of Chemistry (RSC)
dc.titleEnzymatically triggered multifunctional delivery system based on hyaluronic acid micelles
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Lab
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentChemical Science Program
dc.contributor.departmentCore Labs
dc.contributor.departmentImaging and Characterization Core Lab
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalRSC Advances
kaust.personDeng, Lin
kaust.personWang, Guangchao
kaust.personRen, Jian
kaust.personZhang, Bei
kaust.personLi, Wengang
kaust.personKhashab, Niveen M.
kaust.personYan, Jingjing


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