Enzymatically triggered multifunctional delivery system based on hyaluronic acid micelles
Type
ArticleKAUST Department
Advanced Membranes and Porous Materials Research CenterAdvanced Nanofabrication, Imaging and Characterization Core Lab
Biological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
Core Labs
Imaging and Characterization Core Lab
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Date
2012Permanent link to this record
http://hdl.handle.net/10754/562029
Metadata
Show full item recordAbstract
Tumor targetability and stimuli responsivity of drug delivery systems (DDS) are key factors in cancer therapy. Implementation of multifunctional DDS can afford targetability and responsivity at the same time. Herein, cholesterol molecules (Ch) were coupled to hyaluronic acid (HA) backbones to afford amphiphilic conjugates that can self-assemble into stable micelles. Doxorubicin (DOX), an anticancer drug, and superparamagnetic iron oxide (SPIO) nanoparticles (NPs), magnetic resonance imaging (MRI) contrast agents, were encapsulated by Ch-HA micelles and were selectively released in the presence of hyaluronidase (Hyals) enzyme. Cytotoxicity and cell uptake studies were done using three cancer cell lines (HeLa, HepG2 and MCF7) and one normal cell line (WI38). Higher Ch-HA micelles uptake was seen in cancer cells versus normal cells. Consequently, DOX release was elevated in cancer cells causing higher cytotoxicity and enhanced cell death. © 2012 The Royal Society of Chemistry.Publisher
Royal Society of Chemistry (RSC)Journal
RSC Advancesae974a485f413a2113503eed53cd6c53
10.1039/c2ra21888g