A route to hydroxylfluorenes: TsOH-mediated condensation reactions of 1,3-diketones with propargylic alcohols
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
Homogeneous Catalysis Laboratory (HCL)
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/562014
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AbstractAn efficient method of preparing hydroxylfluorenes by TsOH-mediated tandem alkylation/rearrangements of propargylic alcohols with 1,3-diketones is described. These reactions are accomplished in moderate to good yields under mild conditions to offer a straightforward and convenient one step synthetic route to hydroxylfluorene derivatives through a plausible mechanism involving a sequence of dehydration, addition, rearrangement and aromatization. This journal is © The Royal Society of Chemistry 2012.
CitationYao, L.-F., Tan, D., Miao, X., & Huang, K.-W. (2012). A route to hydroxylfluorenes: TsOH-mediated condensation reactions of 1,3-diketones with propargylic alcohols. RSC Advances, 2(19), 7594. doi:10.1039/c2ra20852k
SponsorsWe would like to acknowledge the financial support from the King Abdullah University of Science and Technology and the assistance given by the Core Laboratories.
PublisherRoyal Society of Chemistry (RSC)
RelationsIs Supplemented By:
Yao, L.-F., Tan, D., Miao, X., & Huang, K.-W. (2012). CCDC 879659: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccyjc3x. DOI: 10.5517/ccyjc3x HANDLE: 10754/624710