Show simple item record

dc.contributor.authorMashat, Afnan
dc.contributor.authorDeng, Lin
dc.contributor.authorAltawashi, Azza
dc.contributor.authorSougrat, Rachid
dc.contributor.authorWang, Guangchao
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2015-08-03T09:35:40Z
dc.date.available2015-08-03T09:35:40Z
dc.date.issued2012
dc.identifier.citationMashat, A., Deng, L., Altawashi, A., Sougrat, R., Wang, G., & Khashab, N. M. (2012). Zippered release from polymer-gated carbon nanotubes. Journal of Materials Chemistry, 22(23), 11503. doi:10.1039/c2jm30454f
dc.identifier.issn09599428
dc.identifier.doi10.1039/c2jm30454f
dc.identifier.urihttp://hdl.handle.net/10754/561987
dc.description.abstractA thermosensitive drug delivery system based on polymer-gated carbon nanotubes (CNTs) that are loaded with the anticancer drug doxorubicin (DOX) is herein reported. The development of carbon nanotubes for various biomedical applications is the research focus of many research groups and holds great promise. The major drawback of these materials is the toxicity that is associated with conjugated carbon systems. Functionalization of CNTs with polymers has proved very successful in lowering the toxicity and improving the pharmacokinetic profile. In this work, CNTs are coated with polyethylenimine (PEI) and polyvinyl alcohol (PVA) via the "zipper effect" that provides both support and control over drug release. PEI/PVA provides excellent support to increase DOX loading on the nanocarrier. The system is controlled by changes in temperature due to the complexation (low temperature) and decomplexation (high temperature) of PEI and PVA via hydrogen bonding. The release of DOX was tested in three cell lines (Lung fibroblast (LF), Breast Adenocarcinoma (BA), and HeLa). It was further tested in primary cell lines (Human Dermal Fibroblast adult (HDFa) and Human Dermal Fibroblast neonatal (HDFn)). When the bonds between PEI and PVA are decomplexed at high temperature (≥40 °C), drug release was observed as verified by fluorescence microscopy. There was no drug release at room temperature (25 °C) and a slow release at normal body temperature (37 °C). This system represents a promising method for incorporating stimuli triggered polymer-gated CNTs in future controlled release applications. © 2012 The Royal Society of Chemistry.
dc.description.sponsorshipThe research presented is fully sponsored by King Abdullah University of Science and Technology (KAUST). We thank Dr. Mustafa Ali for all the support and helpful discussions.
dc.publisherRoyal Society of Chemistry (RSC)
dc.titleZippered release from polymer-gated carbon nanotubes
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Lab
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentChemical Science Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentCore Labs
dc.contributor.departmentDesign and Development Support
dc.contributor.departmentEnvironmental Science and Engineering Program
dc.contributor.departmentImaging and Characterization Core Lab
dc.contributor.departmentOffice of the VP
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalJournal of Materials Chemistry
kaust.personMashat, Afnan
kaust.personDeng, Lin
kaust.personAltawashi, Azza
kaust.personSougrat, Rachid
kaust.personWang, Guangchao
kaust.personKhashab, Niveen M.


This item appears in the following Collection(s)

Show simple item record