Asymmetric H-D exchange reactions of fluorinated aromatic ketones
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
KAUST Catalysis Center (KCC)
Chemical Science Program
Physical Sciences and Engineering (PSE) Division
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AbstractChiral bicyclic guanidine catalyzes the asymmetric H-D exchange reactions. Up to 30% ee was achieved. DFT calculations were employed to elucidate and explain the origin of the reaction's stereoselectivity. © 2012 The Royal Society of Chemistry.
SponsorsWe wish to thank the National University of Singapore and King Abdullah University of Science and Technology for their generous financial support.
PublisherRoyal Society of Chemistry (RSC)