Hexafluorobenzene: A powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/561973
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AbstractA dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-l-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C 6F 6. © The Royal Society of Chemistry 2012.
SponsorsWe thank MIUR for financial support and the Spanish MICINN for a Ramon y Cajal contract (RYC-2009-04170).
PublisherRoyal Society of Chemistry (RSC)