Hexafluorobenzene: A powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction
KAUST DepartmentPhysical Sciences and Engineering (PSE) Division
Chemical Science Program
KAUST Catalysis Center (KCC)
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AbstractA dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-l-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C 6F 6. © The Royal Society of Chemistry 2012.
SponsorsWe thank MIUR for financial support and the Spanish MICINN for a Ramon y Cajal contract (RYC-2009-04170).
PublisherRoyal Society of Chemistry (RSC)