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    Porous polymer monoliths functionalized through copolymerization of a C60 fullerene-containing methacrylate monomer for highly efficient separations of small molecules

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    porous polymer.pdf
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    Type
    Article
    Authors
    Chambers, Stuart D.
    Holcombe, Thomas W.
    Švec, František
    Frechet, Jean cc
    KAUST Department
    Chemical Science Program
    Office of the VP
    Physical Science and Engineering (PSE) Division
    Date
    2011-11-02
    Embargo End Date
    2012-11-02
    Permanent link to this record
    http://hdl.handle.net/10754/561958
    
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    Abstract
    Monolithic poly(glycidyl methacrylate-co-ethylene dimethacrylate) and poly(butyl methacrylate-co-ethylene dimethacrylate) capillary columns, which incorporate the new monomer [6,6]-phenyl-C 61-butyric acid 2-hydroxyethyl methacrylate ester, have been prepared and their chromatographic performance have been tested for the separation of small molecules in the reversed phase. While addition of the C60-fullerene monomer to the glycidyl methacrylate-based monolith enhanced column efficiency 18-fold, to 85 000 plates/m at a linear velocity of 0.46 mm/s and a retention factor of 2.6, when compared to the parent monolith, the use of butyl methacrylate together with the carbon nanostructured monomer afforded monolithic columns with an efficiency for benzene exceeding 110 000 plates/m at a linear velocity of 0.32 mm/s and a retention factor of 4.2. This high efficiency is unprecedented for separations using porous polymer monoliths operating in an isocratic mode. Optimization of the chromatographic parameters affords near baseline separation of 6 alkylbenzenes in 3 min with an efficiency of 64 000 plates/m. The presence of 1 wt % or more of water in the polymerization mixture has a large effect on both the formation and reproducibility of the monoliths. Other factors such as nitrogen exposure, polymerization conditions, capillary filling method, and sonication parameters were all found to be important in producing highly efficient and reproducible monoliths. © 2011 American Chemical Society.
    Citation
    Chambers, S. D., Holcombe, T. W., Svec, F., & Fréchet, J. M. J. (2011). Porous Polymer Monoliths Functionalized through Copolymerization of a C60 Fullerene-Containing Methacrylate Monomer for Highly Efficient Separations of Small Molecules. Analytical Chemistry, 83(24), 9478–9484. doi:10.1021/ac202183g
    Sponsors
    All experimental and characterization work performed at the Molecular Foundry, Lawrence Berkeley National Laboratory, and F.S. were supported by the Office of Science, Office of Basic Energy Sciences, Scientific User Facilities Division of the U.S. Department of Energy, under Contract No. DE-AC02-05CH11231. Financial support of S.D.C. and J.M.J.F by a grant from the National Institute of Health (GM48364) is gratefully acknowledged.
    Publisher
    American Chemical Society (ACS)
    Journal
    Analytical Chemistry
    DOI
    10.1021/ac202183g
    PubMed ID
    22044302
    PubMed Central ID
    PMC3418882
    Additional Links
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418882
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418882
    ae974a485f413a2113503eed53cd6c53
    10.1021/ac202183g
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Chemical Science Program

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