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dc.contributor.authorLu, Shiyou
dc.contributor.authorZhao, Huayan
dc.contributor.authorParsons, Eugene P.
dc.contributor.authorXu, Changcheng
dc.contributor.authorKosma, Dylan K.
dc.contributor.authorXu, Xiaojing
dc.contributor.authorChao, Daiyin
dc.contributor.authorLohrey, Gregory T.
dc.contributor.authorBangarusamy, Dhinoth Kumar
dc.contributor.authorWang, Guangchao
dc.contributor.authorBressan, Ray Anthony
dc.contributor.authorJenks, Matthew A.
dc.date.accessioned2015-08-03T09:33:07Z
dc.date.available2015-08-03T09:33:07Z
dc.date.issued2011-09-23
dc.identifier.citationLü, S., Zhao, H., Parsons, E. P., Xu, C., Kosma, D. K., Xu, X., … Jenks, M. A. (2011). The glossyhead1 Allele of ACC1 Reveals a Principal Role for Multidomain Acetyl-Coenzyme A Carboxylase in the Biosynthesis of Cuticular Waxes by Arabidopsis. Plant Physiology, 157(3), 1079–1092. doi:10.1104/pp.111.185132
dc.identifier.issn00320889
dc.identifier.pmid21949210
dc.identifier.doi10.1104/pp.111.185132
dc.identifier.urihttp://hdl.handle.net/10754/561878
dc.description.abstractA novel mutant of Arabidopsis (Arabidopsis thaliana), having highly glossy inflorescence stems, postgenital fusion in floral organs, and reduced fertility, was isolated from an ethyl methanesulfonate-mutagenized population and designated glossyhead1 (gsd1). The gsd1 locus was mapped to chromosome 1, and the causal gene was identified as a new allele of Acetyl-Coenzyme A Carboxylase1 (ACC1), a gene encoding the main enzyme in cytosolic malonyl-coenzyme A synthesis. This, to our knowledge, is the first mutant allele of ACC1 that does not cause lethality at the seed or early germination stage, allowing for the first time a detailed analysis of ACC1 function in mature tissues. Broad lipid profiling of mature gsd1 organs revealed a primary role for ACC1 in the biosynthesis of the very-long-chain fatty acids (C 20:0 or longer) associated with cuticular waxes and triacylglycerols. Unexpectedly, transcriptome analysis revealed that gsd1 has limited impact on any lipid metabolic networks but instead has a large effect on environmental stress-responsive pathways, especially senescence and ethylene synthesis determinants, indicating a possible role for the cytosolic malonyl-coenzyme A-derived lipids in stress response signaling. © 2011 American Society of Plant Biologists. All Rights Reserved.
dc.description.sponsorshipWe are grateful to Dr. Masao Tasaka (Nara Institute of Science and Technology) for providing emb22 and acc1-3 seeds. We also thank Debra Sherman and Chia-Ping Huang of the Purdue University Electron Microscopy Center for support.
dc.publisherAmerican Society of Plant Biologists (ASPB)
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252135
dc.titleThe glossyhead1 allele of acc1 reveals a principal role for multidomain acetyl-coenzyme a carboxylase in the biosynthesis of cuticular waxes by Arabidopsis
dc.typeArticle
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Core Lab
dc.contributor.departmentImaging and Characterization Core Lab
dc.contributor.departmentBioscience Program
dc.contributor.departmentCore Labs
dc.identifier.journalPLANT PHYSIOLOGY
dc.identifier.pmcidPMC3252135
dc.contributor.institutionDepartment of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907-2054, United States
dc.contributor.institutionBiology Department, Brookhaven National Laboratory, Upton NY 11973-5000, United States
dc.contributor.institutionDepartment of Plant Biology, Michigan State University, East Lansing MI 48824, United States
dc.contributor.institutionUnited States Arid Land Agricultural Research Center, United States Department of Agriculture-Agricultural Research Service, Maricopa AZ 85138, United States
kaust.personLu, Shiyou
kaust.personZhao, Huayan
kaust.personBangarusamy, Dhinoth Kumar
kaust.personWang, Guangchao
kaust.personBressan, Ray Anthony
dc.date.published-online2011-09-23
dc.date.published-print2011-11-01


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