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    Effect of passivation on the sensitivity and stability of pentacene transistor sensors in aqueous media

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    Type
    Article
    Authors
    Khan, Hadayat Ullah
    Jang, Junhyuk
    Kim, Jangjoo
    Knoll, Wolfgang
    KAUST Department
    Material Science and Engineering Program
    Physical Science and Engineering (PSE) Division
    Date
    2011-06
    Permanent link to this record
    http://hdl.handle.net/10754/561788
    
    Metadata
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    Abstract
    Charge-detecting biosensors have recently become the focal point of biosensor research, especially research onto organic thin-film transistors (OTFTs), which combine compactness, a low cost, and fast and label-free detection to realize simple and stable in vivo diagnostic systems. We fabricated organic pentacene-based bottom-contact thin-film transistors with an ultra-thin insulating layer of a cyclized perfluoro polymer called CYTOP (Asahi Glass Co., Tokyo, Japan) on SiO2 for operation in aqueous media. The stability and sensitivity of these transistor sensors were examined in aqueous buffer media with solutions of variable pH levels after the passivation of perfluoro polymers with thicknesses ranging from 50 to 300nm. These transistor sensors were further modified with an ultra-thin film (5nm) functional layer for selective BSA/antiBSA detection in aqueous buffer media, demonstrating a detection capability as low as 500nM of concentrated antiBSA. The dissociation constant from the antiBSA detection results was 2.1×10-6M. Thus, this study represents a significant step forward in the development of organic electronics for a disposable and versatile chemical and bio-sensing platform. © 2011 Elsevier B.V.
    Citation
    Khan, H. U., Jang, J., Kim, J.-J., & Knoll, W. (2011). Effect of passivation on the sensitivity and stability of pentacene transistor sensors in aqueous media. Biosensors and Bioelectronics, 26(10), 4217–4221. doi:10.1016/j.bios.2011.03.031
    Sponsors
    H.U.K. acknowledges the financial support from IRTG/1404 (funded by the DFG) and the Max-Planck Society (Germany). J.-J.K. acknowledges the WCU (R31-2008-000-10075-0) and BSR (R15-2008-006-01001-0) support through the NRF funded by the Ministry of Education, Science and Technology of Korea.
    Publisher
    Elsevier BV
    Journal
    Biosensors and Bioelectronics
    DOI
    10.1016/j.bios.2011.03.031
    PubMed ID
    21546238
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bios.2011.03.031
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program

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