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dc.contributor.authorGerhardt, Lutz Christian
dc.contributor.authorWiddows, Kate L.
dc.contributor.authorErol, Melek M.
dc.contributor.authorBurch, Charles W.
dc.contributor.authorSanz-Herrera, José A.
dc.contributor.authorOchoa, Ignacio
dc.contributor.authorStämpfli, Rolf
dc.contributor.authorRoqan, Iman S.
dc.contributor.authorGabe, Simon M.
dc.contributor.authorAnsari, Tahera I.
dc.contributor.authorBoccaccini, Aldo R.
dc.date.accessioned2015-08-03T09:04:31Z
dc.date.available2015-08-03T09:04:31Z
dc.date.issued2011-06
dc.identifier.issn01429612
dc.identifier.pmid21411138
dc.identifier.doi10.1016/j.biomaterials.2011.02.032
dc.identifier.urihttp://hdl.handle.net/10754/561783
dc.description.abstractThe angiogenic properties of micron-sized (m-BG) and nano-sized (n-BG) bioactive glass (BG) filled poly(D,L lactide) (PDLLA) composites were investigated. On the basis of cell culture work investigating the secretion of vascular endothelial growth factor (VEGF) by human fibroblasts in contact with composite films (0, 5, 10, 20 wt %), porous 3D composite scaffolds, optimised with respect to the BG filler content capable of inducing angiogenic response, were produced. The in vivo vascularisation of the scaffolds was studied in a rat animal model and quantified using stereological analyses. The prepared scaffolds had high porosities (81-93%), permeability (k = 5.4-8.6 × 10-9 m2) and compressive strength values (0.4-1.6 MPa) all in the range of trabecular bone. On composite films containing 20 wt % m-BG or n-BG, human fibroblasts produced 5 times higher VEGF than on pure PDLLA films. After 8 weeks of implantation, m-BG and n-BG containing scaffolds were well-infiltrated with newly formed tissue and demonstrated higher vascularisation and percentage blood vessel to tissue (11.6-15.1%) than PDLLA scaffolds (8.5%). This work thus shows potential for the regeneration of hard-soft tissue defects and increased bone formation arising from enhanced vascularisation of the construct. © 2011 Elsevier Ltd.
dc.description.sponsorshipThe authors acknowledge the financial support of King Abdullah University of Science and Technology (KAUST). Special thanks are due to Dr. L Serra (Roche, Germany), Dr. J. Lackey (Insight Biotechnology, UK), C. Akufo-Addo (LGC Standards, UK), Dr. M. Ardakani, E. Ware, R. Chater (all Imperial College London) for technical support and helpful discussions. The authors also acknowledge Prof. W. Stark and D. Mohn (ETH Zurich) for providing the nano-sized BG used.
dc.publisherElsevier BV
dc.subjectAngiogenesis
dc.subjectBioactive glass
dc.subjectBone
dc.subjectComposite scaffold
dc.subjectVascular endothelial growth factor
dc.subjectVascularisation
dc.titleThe pro-angiogenic properties of multi-functional bioactive glass composite scaffolds
dc.typeArticle
dc.contributor.departmentMaterial Science and Engineering Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSemiconductor and Material Spectroscopy (SMS) Laboratory
dc.identifier.journalBiomaterials
dc.contributor.institutionUniv Erlangen Nurnberg, Inst Biomat, D-91058 Erlangen, Germany
dc.contributor.institutionUniv London Imperial Coll Sci Technol & Med, Dept Mat, London SW7 2BP, England
dc.contributor.institutionNorthwick Pk Inst Med Res, Dept Surg Res, Harrow HA1 3UJ, Middx, England
dc.contributor.institutionIstanbul Tech Univ, Dept Chem Engn, TR-34469 Istanbul, Turkey
dc.contributor.institutionUniv Seville, Sch Engn, Seville 41092, Spain
dc.contributor.institutionUniv Zaragoza, Dept Mech Engn, Zaragoza 50018, Spain
dc.contributor.institutionSwiss Fed Labs Mat Sci & Technol, EMPA, Lab Protect & Physiol, CH-9014 St Gallen, Switzerland
dc.contributor.institutionSt Marks Hosp, Dept Gastroenterol Endoscopy, Harrow HA1 3UJ, Middx, England
kaust.personRoqan, Iman S.


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