Show simple item record

dc.contributor.authorZhong, Fangrui
dc.contributor.authorWang, Youqing
dc.contributor.authorHan, Xiaoyu
dc.contributor.authorHuang, Kuo-Wei
dc.contributor.authorLu, Yixin
dc.date.accessioned2015-08-03T09:03:24Z
dc.date.available2015-08-03T09:03:24Z
dc.date.issued2011-03-18
dc.identifier.issn15237060
dc.identifier.pmid21332151
dc.identifier.doi10.1021/ol103145g
dc.identifier.urihttp://hdl.handle.net/10754/561734
dc.description.abstractA series of novel bifunctional phosphine-sulfonamide organic catalysts were designed and readily prepared from natural amino acids, and they were utilized to promote enantioselective aza-Morita-Baylis-Hillman (MBH) reactions. l-Threonine-derived phosphine-sulfonamide 9b was found to be the most efficient catalyst, affording the desired aza-MBH adducts in high yields and with excellent enantioselectivities. © 2011 American Chemical Society.
dc.description.sponsorshipWe are grateful for the generous financial support from the National University of Singapore and the Ministry of Education (MOE) of Singapore (R-143-000-362-112) to Y.L. and from King Abdullah University of Science and Technology to K.-W.H.
dc.publisherAmerican Chemical Society (ACS)
dc.titleL-Threonine-derived novel bifunctional phosphine-sulfonamide catalyst-promoted enantioselective aza-morita-Baylis-Hillman reaction
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentChemical Science Program
dc.contributor.departmentHomogeneous Catalysis Laboratory (HCL)
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalOrganic Letters
dc.contributor.institutionDepartment of Chemistry and Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore
dc.contributor.institutionProvincial Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Jinming Campus, Kaifeng, Henan, 475004, China
kaust.personHuang, Kuo-Wei


This item appears in the following Collection(s)

Show simple item record