L-Threonine-derived novel bifunctional phosphine-sulfonamide catalyst-promoted enantioselective aza-morita-Baylis-Hillman reaction
Type
ArticleKAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionChemical Science Program
Homogeneous Catalysis Laboratory (HCL)
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2011-03-18Permanent link to this record
http://hdl.handle.net/10754/561734
Metadata
Show full item recordAbstract
A series of novel bifunctional phosphine-sulfonamide organic catalysts were designed and readily prepared from natural amino acids, and they were utilized to promote enantioselective aza-Morita-Baylis-Hillman (MBH) reactions. l-Threonine-derived phosphine-sulfonamide 9b was found to be the most efficient catalyst, affording the desired aza-MBH adducts in high yields and with excellent enantioselectivities. © 2011 American Chemical Society.Citation
Zhong, F., Wang, Y., Han, X., Huang, K.-W., & Lu, Y. (2011). l-Threonine-Derived Novel Bifunctional Phosphine−Sulfonamide Catalyst-Promoted Enantioselective Aza-Morita−Baylis−Hillman Reaction. Organic Letters, 13(6), 1310–1313. doi:10.1021/ol103145gSponsors
We are grateful for the generous financial support from the National University of Singapore and the Ministry of Education (MOE) of Singapore (R-143-000-362-112) to Y.L. and from King Abdullah University of Science and Technology to K.-W.H.Publisher
American Chemical Society (ACS)Journal
Organic LettersPubMed ID
21332151ae974a485f413a2113503eed53cd6c53
10.1021/ol103145g
Scopus Count
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