The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: Access to chiral γ-Butenolides and glycerol derivatives
Type
Article
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionKAUST Catalysis Center (KCC)
Chemical Science Program
Physical Sciences and Engineering (PSE) Division
HCL
Date
2011-01-11Metadata
Show full item recordAbstract
Twice as good: The title reaction using the tryptophan-derived bifunctional organic catalyst 1 has been developed. The reported method led to the synthesis of chiral γ-substituted butenolides in excellent yields, with high diastereo- and enantioselectivities. Facile synthesis of chiral glycerol derivatives containing a tertiary hydroxy group has also been demonstrated. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Sponsors
We thank the National University of Singapore and the Ministry of Education (MOE) of Singapore (R-143-000-362-112) for generous financial support.Publisher
Wiley-BlackwellISSN
14337851PubMed ID
21328657Handle URI
http://hdl.handle.net/10754/561702Is Supplemented By
Luo, J., Wang, H., Han, X., Xu, L.-W., Kwiatkowski, J., Huang, K.-W., & Lu, Y. (2011). CCDC 803555: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccvz543DOI:10.5517/ccvz543
HANDLE:http://hdl.handle.net/10754/624624