KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Advanced Nanofabrication, Imaging and Characterization Core Lab
Biological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
Imaging and Characterization Core Lab
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Permanent link to this recordhttp://hdl.handle.net/10754/561664
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AbstractA pH-responsive membrane based on polystyrene-b-poly(4-vinylpyridine) (PS-b-P4VP) block copolymer was developed on a model glass microchip as a promising controlled polymer delivery system. The PS-b-P4VP copolymer assembles into spherical and/or worm-like micelles with styrene block cores and pyridine coronas in selective solvents. The self-assembled worm-like morphology exhibited pH-responsive behaviour due to the protonation of the P4VP block at low pH and it's deprotonation at high pH and thus constituting a switchable "off/on" system. Doxorubicin (Dox) was used as cargo to test the PS-b-P4VP membrane. Luminescence experiments indicated that the membrane was able to store Dox molecules within its micellar structure at neutral pH and then release them as soon as the pH was raised to 8.0. The performance of the cast membrane was predictable and most importantly reproducible. The physiochemical and biological properties were also investigated carefully in terms of morphology, cell viability and cell uptake. This journal is © The Royal Society of Chemistry.
CitationYang, X., Moosa, B. A., Deng, L., Zhao, L., & Khashab, N. M. (2011). pH-triggered micellar membrane for controlled release microchips. Polymer Chemistry, 2(11), 2543. doi:10.1039/c1py00300c
SponsorsThe research presented is fully sponsored by King Abdullah University of Science and Technology (KAUST). The authors thank his excellency minister Ali Ibrahim Al Naimi for his constant support to the research environment at KAUST.
PublisherRoyal Society of Chemistry (RSC)