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    Symbiosis of zeolite-like metal-organic frameworks (rho-ZMOF) and hydrogels: Composites for controlled drug release

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    Type
    Article
    Authors
    Ananthoji, Ramakanth
    Eubank, Jarrod F.
    Nouar, Farid
    Mouttaki, Hasnaa
    Eddaoudi, Mohamed cc
    Harmon, Julie P.
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Biological and Environmental Sciences and Engineering (BESE) Division
    Chemical Science Program
    Functional Materials Design, Discovery and Development (FMD3)
    Physical Science and Engineering (PSE) Division
    Date
    2011
    Permanent link to this record
    http://hdl.handle.net/10754/561655
    
    Metadata
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    Abstract
    The design and synthesis of new finely tunable porous materials has spurred interest in developing novel uses in a variety of systems. Zeolites, inorganic materials with high thermal and mechanical stability, in particular, have been widely examined for use in applications such as catalysis, ion exchange and separation. A relatively new class of inorganic-organic hybrid materials known as metal-organic frameworks (MOFs) have recently surfaced, and many have exhibited their efficiency in potential applications such as ion exchange and drug delivery. A more recent development is the design and synthesis of a subclass of MOFs based on zeolite topologies (i.e. ZMOFs), which often exhibit traits of both zeolites and MOFs. Bio-compatible hydrogels already play an important role in drug delivery systems, but are often limited by stability issues. Thus, the addition of ZMOFs to hydrogel formulations is expected to enhance the hydrogel mechanical properties, and the ZMOF-hydrogel composites should present improved, symbiotic drug storage and release for delivery applications. Herein we present the novel composites of a hydrogel with a zeolite-like metal-organic framework, rho-ZMOF, using 2-hydroxyethyl methacrylate (HEMA), 2,3-dihydroxypropyl methacrylate (DHPMA), N-vinyl-2-pyrolidinone (VP) and ethylene glycol dimethacrylate (EGDMA), and the corresponding drug release. An ultraviolet (UV) polymerization method is employed to synthesize the hydrogels, VP 0, VP 15, VP 30, VP 45 and the ZMOF-VP 30 composite, by varying the VP content (mol%). The rho-ZMOF, VP 30, and ZMOF-VP 30 composite are all tested for the controlled release of procainamide (protonated, PH), an anti-arrhythmic drug, in phosphate buffer solution (PBS) using UV spectroscopy. © 2011 The Royal Society of Chemistry.
    Citation
    Ananthoji, R., Eubank, J. F., Nouar, F., Mouttaki, H., Eddaoudi, M., & Harmon, J. P. (2011). Symbiosis of zeolite-like metal–organic frameworks (rho-ZMOF) and hydrogels: Composites for controlled drug release. Journal of Materials Chemistry, 21(26), 9587. doi:10.1039/c1jm11075f
    Publisher
    Royal Society of Chemistry (RSC)
    Journal
    Journal of Materials Chemistry
    DOI
    10.1039/c1jm11075f
    ae974a485f413a2113503eed53cd6c53
    10.1039/c1jm11075f
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Functional Materials Design, Discovery and Development (FMD3); Chemical Science Program

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