Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines

Type
Article
Authors
Zhang, Yan
Kee, Choonwee
Lee, Richmond
Fu, Xiao
Soh, J. Y T
Loh, E. M F
Huang, Kuo-Wei cc
Tan, Choonhong
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) Division
KAUST Catalysis Center (KCC)
Chemical Science Program
Physical Sciences and Engineering (PSE) Division
HCL
Date
2011

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Abstract
An amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities. © The Royal Society of Chemistry.
Publisher
Royal Society of Chemistry (RSC)
Journal
Chemical Communications
ISSN
13597345
DOI
10.1039/c0cc05840h
PubMed ID
21336394
Handle URI
http://hdl.handle.net/10754/561648
Is Supplemented By
Zhang, Y., Kee, C. W., Lee, R., Fu, X., Soh, J. Y.-T., Loh, E. M. F., … Tan, C.-H. (2011). CCDC 806368: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccw22ww
DOI:10.5517/ccw22ww
HANDLE:http://hdl.handle.net/10754/624627
Zhang, Y., Kee, C. W., Lee, R., Fu, X., Soh, J. Y.-T., Loh, E. M. F., … Tan, C.-H. (2011). CCDC 806369: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccw22xx
DOI:10.5517/ccw22xx
HANDLE:http://hdl.handle.net/10754/624628
Collections
Articles; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC); Biological and Environmental Sciences and Engineering (BESE) Division