Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines

Type
Article
Authors
Zhang, Yan
Kee, Choonwee
Lee, Richmond
Fu, Xiao
Soh, J. Y T
Loh, E. M F
Huang, Kuo-Wei cc
Tan, Choonhong
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
Homogeneous Catalysis Laboratory (HCL)
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2011
Permanent link to this record
http://hdl.handle.net/10754/561648

Metadata
Show full item record
Abstract
An amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities. © The Royal Society of Chemistry.
Citation
Zhang, Y., Kee, C. W., Lee, R., Fu, X., Soh, J. Y.-T., Loh, E. M. F., … Tan, C.-H. (2011). Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines. Chemical Communications, 47(13), 3897. doi:10.1039/c0cc05840h
Publisher
Royal Society of Chemistry (RSC)
Journal
Chemical Communications
DOI
10.1039/c0cc05840h
PubMed ID
21336394
Relations
Is Supplemented By:
  • [Dataset]
    Zhang, Y., Kee, C. W., Lee, R., Fu, X., Soh, J. Y.-T., Loh, E. M. F., … Tan, C.-H. (2011). CCDC 806368: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccw22ww. DOI: 10.5517/ccw22ww HANDLE: 10754/624627
  • [Dataset]
    Zhang, Y., Kee, C. W., Lee, R., Fu, X., Soh, J. Y.-T., Loh, E. M. F., … Tan, C.-H. (2011). CCDC 806369: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccw22xx. DOI: 10.5517/ccw22xx HANDLE: 10754/624628
Collections
Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Physical Science and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC)