Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines

Type
Article
Authors
Zhang, Yan
Kee, Choonwee
Lee, Richmond
Fu, Xiao
Soh, J. Y T
Loh, E. M F
Huang, Kuo-Wei cc
Tan, Choonhong
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
Homogeneous Catalysis Laboratory (HCL)
KAUST Catalysis Center (KCC)
Physical Sciences and Engineering (PSE) Division
Date
2011
Permanent link to this record
http://hdl.handle.net/10754/561648

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Abstract
An amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities. © The Royal Society of Chemistry.
Publisher
Royal Society of Chemistry (RSC)
Journal
Chemical Communications
ISSN
13597345
DOI
10.1039/c0cc05840h
PubMed ID
21336394
Collections
Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC)