Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes

Abstract
A chloride ion-catalyzed generation of difluorocarbene from a relatively non-toxic and inexpensive precursor, Me3SiCF2Cl (1), under mild and neutral conditions leads to an efficient preparation of gem-difluorocyclopropenes and difluorocyclopropanes through [2 + 1] cycloaddition reactions with alkynes and alkenes, respectively. © 2011 The Royal Society of Chemistry.

Citation
Wang, F., Zhang, W., Zhu, J., Li, H., Huang, K.-W., & Hu, J. (2011). Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes. Chem. Commun., 47(8), 2411–2413. doi:10.1039/c0cc04548a

Acknowledgements
This work was supported by CAS and NFSC (20772144, 20825209, 20832008) to J.H. and by a KAUST baseline funding to K.-W.H.

Publisher
Royal Society of Chemistry (RSC)

Journal
Chem. Commun.

DOI
10.1039/c0cc04548a

PubMed ID
21170456

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