Type
ArticleKAUST Department
Red Sea Research Center (RSRC)Biological and Environmental Sciences and Engineering (BESE) Division
Marine Science Program
Reef Genomics Lab
Date
2010-12-06Online Publication Date
2010-12-06Print Publication Date
2011-03-15Embargo End Date
2011-12-06Permanent link to this record
http://hdl.handle.net/10754/561640
Metadata
Show full item recordAbstract
Genome-wide transcriptional changes in development provide important insight into mechanisms underlying growth, differentiation, and patterning. However, such large-scale developmental studies have been limited to a few representatives of Ecdysozoans and Chordates. Here, we characterize transcriptomes of embryonic, larval, and metamorphic development in the marine mollusc Aplysia californica and reveal novel molecular components associated with life history transitions. Specifically, we identify more than 20 signal peptides, putative hormones, and transcription factors in association with early development and metamorphic stages-many of which seem to be evolutionarily conserved elements of signal transduction pathways. We also characterize genes related to biomineralization-a critical process of molluscan development. In summary, our experiment provides the first large-scale survey of gene expression in mollusc development, and complements previous studies on the regulatory mechanisms underlying body plan patterning and the formation of larval and juvenile structures. This study serves as a resource for further functional annotation of transcripts and genes in Aplysia, specifically and molluscs in general. A comparison of the Aplysia developmental transcriptome with similar studies in the zebra fish Danio rerio, the fruit fly Drosophila melanogaster, the nematode Caenorhabditis elegans, and other studies on molluscs suggests an overall highly divergent pattern of gene regulatory mechanisms that are likely a consequence of the different developmental modes of these organisms. © 2010 Wiley-Liss, Inc., A Wiley Company.Sponsors
Grant Sponsors: Swiss National Science Foundation Stipendium fuer Angehende Forscher, Brain Research Foundation; NSERC; Grant number: C400230; Grant Sponsor: CFI; Grant number: 460175; Grant Sponsor: NIH; Grant numbers: P50HG002806; R01NS06076; RR025699; Grant Sponsor: NSF; Grant numbers: 0744649; DEB-0542330.Publisher
WileyPubMed ID
21328528PubMed Central ID
PMC4028319Additional Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028319https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028319
ae974a485f413a2113503eed53cd6c53
10.1002/jez.b.21383
Scopus Count
Related articles
- The transcriptome of the early life history stages of the California Sea Hare Aplysia californica.
- Authors: Fiedler TJ, Hudder A, McKay SJ, Shivkumar S, Capo TR, Schmale MC, Walsh PJ
- Issue date: 2010 Jun
- Whole-transcriptome changes in gene expression accompany aging of sensory neurons in Aplysia californica.
- Authors: Greer JB, Schmale MC, Fieber LA
- Issue date: 2018 Jul 11
- Berry skin development in Norton grape: distinct patterns of transcriptional regulation and flavonoid biosynthesis.
- Authors: Ali MB, Howard S, Chen S, Wang Y, Yu O, Kovacs LG, Qiu W
- Issue date: 2011 Jan 10
- Global analysis of dorsoventral patterning in the wasp Nasonia reveals extensive incorporation of novelty in a regulatory network.
- Authors: Pers D, Buchta T, Özüak O, Wolff S, Pietsch JM, Memon MB, Roth S, Lynch JA
- Issue date: 2016 Aug 1
- Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia.
- Authors: Kadakkuzha BM, Akhmedov K, Capo TR, Carvalloza AC, Fallahi M, Puthanveettil SV
- Issue date: 2013 Dec 14