Type
ArticleAuthors
Mahfouz, Magdy M.
KAUST Department
Biological and Environmental Science and Engineering (BESE) DivisionBioscience Program
Center for Desert Agriculture
Laboratory for Genome Engineering
Plant Science
Plant Science Program
Date
2014-10-28Online Publication Date
2014-10-28Print Publication Date
2010-07Permanent link to this record
http://hdl.handle.net/10754/561530
Metadata
Show full item recordAbstract
Epigenetic RNA based gene silencing mechanisms play a major role in genome stability and control of gene expression. Transcriptional gene silencing via RNA-directed DNA methylation (RdDM) guides the epigenetic regulation of the genome in response to disease states, growth, developmental and stress signals. RdDM machinery is composed of proteins that produce and modify 24-nt- long siRNAs, recruit the RdDM complex to genomic targets, methylate DNA and remodel chromatin. The final DNA methylation pattern is determined by either DNA methyltransferase alone or by the combined action of DNA methyltransferases and demethylases. The dynamic interaction between RdDM and demethylases may render the plant epigenome plastic to growth, developmental, and environmental cues. The epigenome plasticity may allow the plant genome to assume many epigenomes and to have the right epigenome at the right time in response to intracellular or extracellular stimuli. This review discusses recent advances in RdDM research and considers future perspectives.Citation
Mahfouz, M. M. (2010). RNA-directed DNA methylation. Plant Signaling & Behavior, 5(7), 806–816. doi:10.4161/psb.5.7.11695Publisher
Informa UK LimitedJournal
Plant Signaling & BehaviorPubMed ID
20421728PubMed Central ID
PMC3115029Additional Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115029ae974a485f413a2113503eed53cd6c53
10.4161/psb.5.7.11695
Scopus Count
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