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dc.contributor.authorYi, Ying
dc.contributor.authorZaher, Amir
dc.contributor.authorYassine, Omar
dc.contributor.authorKosel, Jürgen
dc.contributor.authorFoulds, Ian G.
dc.date.accessioned2015-07-28T13:04:35Z
dc.date.available2015-07-28T13:04:35Z
dc.date.issued2015-07-22
dc.identifier.citationA remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve 2015, 9 (5):052608 Biomicrofluidics
dc.identifier.issn1932-1058
dc.identifier.pmid26339328
dc.identifier.doi10.1063/1.4927436
dc.identifier.urihttp://hdl.handle.net/10754/561187
dc.description.abstractImplantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during the limited valve's closing time. The amount of body liquid that refills the drug reservoir can further dissolve the solid drug, forming a reproducible drug solution for the next dose. By repeatedly turning on and off the electromagnetic field, the drug dose can be cyclically released, and the exit port of the device is effectively controlled.
dc.publisherAIP Publishing
dc.relation.urlhttp://scitation.aip.org/content/aip/journal/bmf/9/5/10.1063/1.4927436
dc.rightsArchived with thanks to Biomicrofluidics
dc.titleA remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve
dc.typeArticle
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.identifier.journalBiomicrofluidics
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionSchool of Engineering, University of British Columbia (UBC), Kelowna, British Columbia V1V 1V7, Canada
dc.contributor.institutionSchool of Engineering, University of British Columbia (UBC), Kelowna, British Columbia V1V 1V7, Canada
dc.contributor.institutionSchool of Engineering, University of British Columbia (UBC), Kelowna, British Columbia V1V 1V7, Canada
kaust.personYassine, Omar
kaust.personKosel, Jürgen
kaust.personFoulds, Ian G.
refterms.dateFOA2018-06-13T13:05:22Z
dc.date.published-online2015-07-22
dc.date.published-print2015-09


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