A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve
Permanent link to this recordhttp://hdl.handle.net/10754/561187
MetadataShow full item record
AbstractImplantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during the limited valve's closing time. The amount of body liquid that refills the drug reservoir can further dissolve the solid drug, forming a reproducible drug solution for the next dose. By repeatedly turning on and off the electromagnetic field, the drug dose can be cyclically released, and the exit port of the device is effectively controlled.
CitationA remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve 2015, 9 (5):052608 Biomicrofluidics
- A cyclically actuated electrolytic drug delivery device.
- Authors: Yi Y, Buttner U, Foulds IG
- Issue date: 2015 Sep 7
- Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes.
- Authors: Zaher A, Li S, Wolf KT, Pirmoradi FN, Yassine O, Lin L, Khashab NM, Kosel J
- Issue date: 2015 Sep
- Electromagnetic liquid pistons for capillarity-based pumping.
- Authors: Malouin BA Jr, Vogel MJ, Olles JD, Cheng L, Hirsa AH
- Issue date: 2011 Feb 7
- Wireless implantable chip with integrated nitinol-based pump for radio-controlled local drug delivery.
- Authors: Fong J, Xiao Z, Takahata K
- Issue date: 2015 Feb 21
- Micropumping of liquid by directional growth and selective venting of gas bubbles.
- Authors: Meng DD, Kim CJ
- Issue date: 2008 Jun