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    A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve

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    Type
    Article
    Authors
    Yi, Ying
    Zaher, Amir cc
    Yassine, Omar cc
    Kosel, Jürgen cc
    Foulds, Ian G.
    KAUST Department
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Physical Science and Engineering (PSE) Division
    Sensing, Magnetism and Microsystems Lab
    Date
    2015-07-22
    Online Publication Date
    2015-07-22
    Print Publication Date
    2015-09
    Permanent link to this record
    http://hdl.handle.net/10754/561187
    
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    Abstract
    Implantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during the limited valve's closing time. The amount of body liquid that refills the drug reservoir can further dissolve the solid drug, forming a reproducible drug solution for the next dose. By repeatedly turning on and off the electromagnetic field, the drug dose can be cyclically released, and the exit port of the device is effectively controlled.
    Citation
    A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve 2015, 9 (5):052608 Biomicrofluidics
    Publisher
    AIP Publishing
    Journal
    Biomicrofluidics
    DOI
    10.1063/1.4927436
    PubMed ID
    26339328
    Additional Links
    http://scitation.aip.org/content/aip/journal/bmf/9/5/10.1063/1.4927436
    ae974a485f413a2113503eed53cd6c53
    10.1063/1.4927436
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Electrical and Computer Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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