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dc.contributor.authorZhou, Bingpu
dc.contributor.authorGao, Xinghua
dc.contributor.authorWang, Cong
dc.contributor.authorYe, Ziran
dc.contributor.authorGao, Yibo
dc.contributor.authorXie, Jiao
dc.contributor.authorWu, Xiaoxiao
dc.contributor.authorWen, Weijia
dc.date.accessioned2015-07-27T12:16:08Z
dc.date.available2015-07-27T12:16:08Z
dc.date.issued2015-07-30
dc.identifier.citationFunctionalized PDMS with versatile and scalable surface roughness gradients for cell culture 2015:150721053642001 ACS Applied Materials & Interfaces
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.doi10.1021/acsami.5b04032
dc.identifier.urihttp://hdl.handle.net/10754/561062
dc.description.abstractThis manuscript describes a simple and versatile approach to engineering surface roughness gradients via combination of microfluidics and photo-polymerization. Through UV-mediated polymerization, N-isopropylacrylamide with concentration gradients are successfully grafted onto PDMS surface, leading to diverse roughness degrees on the obtained PDMS substrate. Furthermore, the extent of surface roughness can be controllably regulated via tuning the flow rate ratio between the monomer solution and deionized water. Average roughness ranging from 8.050 nm to 151.68 nm has well been achieved in this work. Such PDMS samples are also demonstrated to be capable of working as supporting substrates for controlling cell adhesion or detachment. Due to the different degrees of surface roughness on a single substrate, our method provides an effective approach for designing advanced surafecs for cell culture. Finally, the thermosensitive property of N-isopropylacrylamide makes our sample furnish as another means for controlling the cell detachment from the substrates with correspondence to the surrounding temperature.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acsami.5b04032
dc.titleFunctionalized PDMS with versatile and scalable surface roughness gradients for cell culture
dc.typeArticle
dc.identifier.journalACS Applied Materials & Interfaces
dc.contributor.institutionNano Science and Technology Program, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
dc.contributor.institutionBiomedical Research Institute, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, People’s Republic of China
dc.contributor.institutionDepartment of Physics, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
dc.contributor.institutionEnvironmental Science Programs, School of Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
dc.contributor.institutionThe Soft Matter and Interdisciplinary Research Inst itute, College of Physics, Chongqing University, Chongqing, China
kaust.personZhou, Bingpu
kaust.personWang, Cong
kaust.personWen, Weijia
dc.date.published-online2015-07-30
dc.date.published-print2015-08-12


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