Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging

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Type
Article
Authors
Fatieiev, Yevhen cc
Croissant, Jonas G.
Julfakyan, Khachatur cc
Deng, Lin cc
Anjum, Dalaver H. cc
Gurinov, Andrei cc
Khashab, Niveen M. cc
KAUST Department
Smart Hybrid Materials (SHMs) lab
Advanced Membranes and Porous Materials Research Center
Advanced Nanofabrication and Thin Film Core Lab
Imaging and Characterization Core Lab
Date
2015-06-30

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Abstract
Non-aggregated dense bridged silsesquioxane (BS) nanoparticles based on nature-inspired oxamide bridges are shown to degrade in simulated biological media upon cleavage with endopeptidase. Fluorescent BS nanoprobes with incorporated fluorescein dyes were applied for in-vitro imaging in cancer cells.
Citation
Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging 2015 Nanoscale
Publisher
Royal Society of Chemistry (RSC)
Journal
Nanoscale
ISSN
2040-3364
2040-3372
DOI
10.1039/C5NR03065J
PubMed ID
26165456
Handle URI
http://hdl.handle.net/10754/558874
Additional Links
http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR03065J
Collections
Articles; Advanced Membranes and Porous Materials Research Center; Advanced Nanofabrication, Imaging and Characterization Core Lab; Controlled Release and Delivery Laboratory