Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging

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Type
Article
Authors
Fatieiev, Yevhen cc
Croissant, Jonas G.
Julfakyan, Khachatur cc
Deng, Lin cc
Anjum, Dalaver H. cc
Gurinov, Andrei cc
Khashab, Niveen M. cc
KAUST Department
Advanced Membranes and Porous Materials Research Center
Chemical Science Program
Electron Microscopy
Entrepreneurship Center
Imaging and Characterization Core Lab
Investment Fund
NMR
Nanofabrication Core Lab
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Date
2015
Permanent link to this record
http://hdl.handle.net/10754/558874

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Abstract
Non-aggregated dense bridged silsesquioxane (BS) nanoparticles based on nature-inspired oxamide bridges are shown to degrade in simulated biological media upon cleavage with endopeptidase. Fluorescent BS nanoprobes with incorporated fluorescein dyes were applied for in-vitro imaging in cancer cells.
Citation
Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging 2015 Nanoscale
Publisher
Royal Society of Chemistry (RSC)
Journal
Nanoscale
DOI
10.1039/C5NR03065J
PubMed ID
26165456
Additional Links
http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR03065J
Collections
Nanofabrication Core Lab; Physical Science and Engineering (PSE) Division; Chemical Science Program; Controlled Release and Delivery Laboratory; Imaging and Characterization Core Lab; Advanced Membranes and Porous Materials Research Center; Articles