Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging
Croissant, Jonas G.
Anjum, Dalaver H.
Khashab, Niveen M.
KAUST DepartmentSmart Hybrid Materials (SHMs) lab
Advanced Membranes and Porous Materials Research Center
Advanced Nanofabrication and Thin Film Core Lab
Imaging and Characterization Core Lab
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AbstractNon-aggregated dense bridged silsesquioxane (BS) nanoparticles based on nature-inspired oxamide bridges are shown to degrade in simulated biological media upon cleavage with endopeptidase. Fluorescent BS nanoprobes with incorporated fluorescein dyes were applied for in-vitro imaging in cancer cells.
CitationEnzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging 2015 Nanoscale
PublisherRoyal Society of Chemistry (RSC)
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