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dc.contributor.authorBen Khadra, Yousra
dc.contributor.authorFerrario, Cinzia
dc.contributor.authorDi Benedetto, Cristiano
dc.contributor.authorSaid, Khaled
dc.contributor.authorBonasoro, Francesco
dc.contributor.authorCandia Carnevali, M. Daniela
dc.contributor.authorSugni, Michela
dc.date.accessioned2015-06-30T14:16:12Z
dc.date.available2015-06-30T14:16:12Z
dc.date.issued2015-07-27
dc.identifier.citationWound repair during arm regeneration in the red starfish Echinaster sepositus 2015:n/a Wound Repair and Regeneration
dc.identifier.issn10671927
dc.identifier.pmid26111373
dc.identifier.doi10.1111/wrr.12333
dc.identifier.urihttp://hdl.handle.net/10754/558700
dc.description.abstractStarfish can regenerate entire arms following their loss by both autotomic and traumatic amputation. Although the overall regenerative process has been studied several times in different asteroid species, there is still a considerable gap of knowledge as far as the detailed aspects of the repair phase at tissue and cellular level are concerned, particularly in post-traumatic regeneration. The present work is focused on the arm regeneration model in the Mediterranean red starfish Echinaster sepositus; in order to describe the early cellular mechanisms of arm regeneration following traumatic amputation, different microscopy techniques were employed. In E. sepositus, the repair phase was characterized by prompt wound healing by a syncytial network of phagocytes and re-epithelialisation followed by a localized subepidermal oedematous area formation. Scattered and apparently undifferentiated cells, intermixed with numerous phagocytes, were frequently found in the wound area during these first stages of regeneration and extensive dedifferentiation phenomena were seen at the level of the stump, particularly in the muscle bundles. A true localized blastema did not form. Our results confirm that regeneration in asteroids mainly relies on morphallactic processes, consisting in extensive rearrangement of the existing tissues which contribute to the new tissues through cell dedifferentiation, re-differentiation and/or migration. This article is protected by copyright. All rights reserved.
dc.publisherWiley
dc.relation.urlhttp://doi.wiley.com/10.1111/wrr.12333
dc.rightsThis is the peer reviewed version of the following article: Ben Khadra, Yousra, Cinzia Ferrario, Cristiano Di Benedetto, Khaled Said, Francesco Bonasoro, M. Daniela Candia Carnevali, and Michela Sugni. "Wound repair during arm regeneration in the red starfish Echinaster sepositus." Wound Repair and Regeneration (2015)., which has been published in final form at http://doi.wiley.com/10.1111/wrr.12333. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
dc.subjectwound healing
dc.subjectsubepidermal oedematous area
dc.subjectrepair phase
dc.subjectarm regeneration
dc.subjectEchinaster sepositus
dc.subjectmorphallaxis
dc.titleWound repair during arm regeneration in the red starfish Echinaster sepositus
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalWound Repair and Regeneration
dc.eprint.versionPost-print
dc.contributor.institutionLaboratoire de Recherche, Génétique, Biodiversité et Valorisation des Bioressources, Institut Supérieur de Biotechnologie de Monastir; Université de Monastir; Monastir Tunisia
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italy
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italy
dc.contributor.institutionLaboratoire de Recherche, Génétique, Biodiversité et Valorisation des Bioressources, Institut Supérieur de Biotechnologie de Monastir; Université de Monastir; Monastir Tunisia
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italy
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italy
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italy
kaust.personDi Benedetto, Cristiano
refterms.dateFOA2016-06-24T00:00:00Z
dc.date.published-online2015-07-27
dc.date.published-print2015-07


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