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    How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions

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    1-s2.0-S0079610715000760-main.pdf
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    Description:
    Main article
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    Type
    Article
    Authors
    Walkiewicz, Katarzyna Wiktoria
    Girault, Jean-Antoine
    Arold, Stefan T. cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Date
    2015-06-18
    Online Publication Date
    2015-06-18
    Print Publication Date
    2015-10
    Permanent link to this record
    http://hdl.handle.net/10754/558299
    
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    Abstract
    The focal adhesion kinase (FAK) and the related protein-tyrosine kinase 2-beta (Pyk2) are highly versatile multidomain scaffolds central to cell adhesion, migration, and survival. Due to their key role in cancer metastasis, understanding and inhibiting their functions are important for the development of targeted therapy. Because FAK and Pyk2 are involved in many different cellular functions, designing drugs with partial and function-specific inhibitory effects would be desirable. Here, we summarise recent progress in understanding the structural mechanism of how the tug-of-war between intramolecular and intermolecular interactions allows these protein ‘nanomachines’ to become activated in a site-specific manner.
    Citation
    How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions 2015 Progress in Biophysics and Molecular Biology
    Publisher
    Elsevier BV
    Journal
    Progress in Biophysics and Molecular Biology
    DOI
    10.1016/j.pbiomolbio.2015.06.001
    PubMed ID
    26093249
    Additional Links
    http://linkinghub.elsevier.com/retrieve/pii/S0079610715000760
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.pbiomolbio.2015.06.001
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Computational Bioscience Research Center (CBRC)

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