How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions
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Main article
Type
ArticleKAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Computational Bioscience Research Center (CBRC)
Date
2015-06-18Online Publication Date
2015-06-18Print Publication Date
2015-10Permanent link to this record
http://hdl.handle.net/10754/558299
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The focal adhesion kinase (FAK) and the related protein-tyrosine kinase 2-beta (Pyk2) are highly versatile multidomain scaffolds central to cell adhesion, migration, and survival. Due to their key role in cancer metastasis, understanding and inhibiting their functions are important for the development of targeted therapy. Because FAK and Pyk2 are involved in many different cellular functions, designing drugs with partial and function-specific inhibitory effects would be desirable. Here, we summarise recent progress in understanding the structural mechanism of how the tug-of-war between intramolecular and intermolecular interactions allows these protein ‘nanomachines’ to become activated in a site-specific manner.Citation
How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions 2015 Progress in Biophysics and Molecular BiologyPublisher
Elsevier BVPubMed ID
26093249Additional Links
http://linkinghub.elsevier.com/retrieve/pii/S0079610715000760ae974a485f413a2113503eed53cd6c53
10.1016/j.pbiomolbio.2015.06.001
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