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dc.contributor.authorAouad, Mohamed Reda
dc.contributor.authorMessali, Mouslim
dc.contributor.authorRezki, Nadjet
dc.contributor.authorAli, Adeeb Al-Sheikh
dc.contributor.authorLesimple, Alain
dc.date.accessioned2015-06-15T13:23:11Z
dc.date.available2015-06-15T13:23:11Z
dc.date.issued2015-05-23
dc.identifier.citationSynthesis and characterization of some novel 1,2,4-triazoles, 1,3,4-thiadiazoles and Schiff bases incorporating imidazole moiety as potential antimicrobial agents 2015, 65 (2) Acta Pharmaceutica
dc.identifier.issn1846-9558
dc.identifier.doi10.1515/acph-2015-0011
dc.identifier.urihttp://hdl.handle.net/10754/556925
dc.description.abstract(1,4,5-Triphenylimidazol-2-yl-thio)butyric acid hydrazide (3) was obtained via alkylation of 1,4,5-triphenylimidazol-2- thiol (1) with ethylbromobutyrate, followed by addition of hydrazine hydrate. Treatment of acid hydrazide 3 with carbon disulfide in an ethanolic potassium hydroxide solution gave the intermediate potassium dithiocarbazinate salt, which was cyclized to 4-amino-5-[(1,4,5-triphenylimidazol- -2-yl)thiopropyl]-2H-1,2,4-triazole-3-thione (4) in the presence of hydrazine hydrate. Condensation of compound 3 with alkyl/arylisothiocyanate afforded the corresponding 1-[4-(1,4,5-triphenylimidazol-2-ylthio)butanoyl]-4-alkyl/arylthiosemicarbazides (5-7), which upon refluxing with sodium hydroxide, yielded the corresponding 1,2,4-triazole - -3-thiols 8-10. Under acidic conditions, compounds 4-6 were converted to aminothiadiazoles 11-13. Moreover, the series of Schiff bases 14-18 were synthesized from the condensation of compound 3 with different aromatic aldehydes. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral analyses. They were also preliminarily screened for their antimicrobial activity.
dc.publisherWalter de Gruyter GmbH
dc.relation.urlhttp://www.degruyter.com/view/j/acph.2015.65.issue-2/acph-2015-0011/acph-2015-0011.xml
dc.rightsArchived with thanks to Acta Pharmaceutica. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0) http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectantimicrobial activity
dc.subjectSchiff bases
dc.subject1,3,4-thiadiazole
dc.subject1,2,4-triazole
dc.subjectimidazole
dc.titleSynthesis and characterization of some novel 1,2,4-triazoles, 1,3,4-thiadiazoles and Schiff bases incorporating imidazole moiety as potential antimicrobial agents
dc.typeArticle
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentAnalytical Core Lab
dc.identifier.journalActa Pharmaceutica
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Chemistry Faculty of Sciences, Taibah University Al-Madinah Al-Munawarah P.O. Box 30002, Saudi Arabia
dc.contributor.institutionDepartment of Chemistry, Faculty of Sciences, University of Sciences and Technology Mohamed Boudiaf Laboratoire de Chimie and Electrochimie des Complexes Métalliques (LCECM) USTO-MB, P.O. Box 1505 Oran El M`nouar, Algeria
kaust.personLesimple, Alain
refterms.dateFOA2018-06-14T07:08:05Z


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