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    The draft genome of Mycobacterium aurum, a potential model organism for investigating drugs against Mycobacterium tuberculosis and Mycobacterium leprae

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    Description:
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    Type
    Article
    Authors
    Phelan, Jody
    Maitra, Arundhati
    McNerney, Ruth cc
    Nair, Mridul
    Gupta, Antima
    Coll, Francesc cc
    Pain, Arnab cc
    Bhakta, Sanjib
    Clark, Taane G. cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Date
    2015-06-05
    Online Publication Date
    2015-06-05
    Print Publication Date
    2015-09
    Permanent link to this record
    http://hdl.handle.net/10754/556900
    
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    Abstract
    Mycobacterium aurum (M. aurum) is an environmental mycobacteria that has previously been used in studies of anti-mycobacterial drugs due to its fast growth rate and low pathogenicity. The M. aurum genome has been sequenced and assembled into 46 contigs, with a total length of 6.02 Mb containing 5684 annotated protein-coding genes. A phylogenetic analysis using whole genome alignments positioned M. aurum close to Mycobacterium vaccae and Mycobacterium vanbaalenii, within a clade related to fast-growing mycobacteria. Large-scale genomic rearrangements were identified by comparing the M. aurum genome to those of Mycobacterium tuberculosis and Mycobacterium leprae. M. aurum orthologous genes implicated in resistance to anti-tuberculosis drugs in M. tuberculosis were observed. The sequence identity at the DNA level varied from 68.6% for pncA (pyrazinamide drug-related) to 96.2% for rrs (streptomycin, capreomycin). We observed two homologous genes encoding the catalase-peroxidase enzyme (katG) that is associated with resistance to isoniazid. Similarly, two embB homologues were identified in the M. aurum genome. In addition to describing for the first time the genome of M. aurum, this work provides a resource to aid the use of M. aurum in studies to develop improved drugs for the pathogenic mycobacteria M. tuberculosis and M. leprae.
    Citation
    The draft genome of Mycobacterium aurum, a potential model organism for investigating drugs against Mycobacterium tuberculosis and Mycobacterium leprae 2015 International Journal of Mycobacteriology
    Publisher
    Medknow
    Journal
    International Journal of Mycobacteriology
    DOI
    10.1016/j.ijmyco.2015.05.001
    Additional Links
    http://linkinghub.elsevier.com/retrieve/pii/S2212553115000783
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijmyco.2015.05.001
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Computational Bioscience Research Center (CBRC)

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