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    The Salmonella effector protein SpvC, a phosphothreonine lyase is functional in plant cells

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    fmicb-05-00548.pdf
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    Type
    Article
    Authors
    Neumann, Christina
    Fraiture, Malou
    Hernàndez-Reyes, Casandra
    Akum, Fidele N.
    Virlogeux-Payant, Isabelle
    Chen, Ying cc
    Pateyron, Stephanie
    Colcombet, Jean
    Kogel, Karl-Heinz
    Hirt, Heribert cc
    Brunner, Frédéric
    Schikora, Adam
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Desert Agriculture Initiative
    Plant Science
    Plant Science Program
    Date
    2014-10-17
    Permanent link to this record
    http://hdl.handle.net/10754/555860
    
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    Abstract
    Salmonella is one of the most prominent causes of food poisoning and growing evidence indicates that contaminated fruits and vegetables are an increasing concern for human health. Successful infection demands the suppression of the host immune system, which is often achieved via injection of bacterial effector proteins into host cells. In this report we present the function of Salmonella effector protein in plant cell, supporting the new concept of trans-kingdom competence of this bacterium. We screened a range of Salmonella Typhimurium effector proteins for interference with plant immunity. Among these, the phosphothreonine lyase SpvC attenuated the induction of immunity-related genes when present in plant cells. Using in vitro and in vivo systems we show that this effector protein interacts with and dephosphorylates activated Arabidopsis Mitogen-activated Protein Kinase 6 (MPK6), thereby inhibiting defense signaling. Moreover, the requirement of Salmonella SpvC was shown by the decreased proliferation of the ΔspvC mutant in Arabidopsis plants. These results suggest that some Salmonella effector proteins could have a conserved function during proliferation in different hosts. The fact that Salmonella and other Enterobacteriaceae use plants as hosts strongly suggests that plants represent a much larger reservoir for animal pathogens than so far estimated.
    Citation
    The Salmonella effector protein SpvC, a phosphothreonine lyase is functional in plant cells 2014, 5 Frontiers in Microbiology
    Publisher
    Frontiers Media SA
    Journal
    Frontiers in Microbiology
    DOI
    10.3389/fmicb.2014.00548
    Additional Links
    http://journal.frontiersin.org/article/10.3389/fmicb.2014.00548/abstract
    ae974a485f413a2113503eed53cd6c53
    10.3389/fmicb.2014.00548
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Biological and Environmental Sciences and Engineering (BESE) Division; Plant Science Program; Desert Agriculture Initiative; Desert Agriculture Initiative

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