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    Coevolution within a transcriptional network by compensatory trans and cis mutations

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    Type
    Article
    Authors
    Kuo, D.
    Licon, K.
    Bandyopadhyay, S.
    Chuang, R.
    LUO, C.
    Catalana, J.
    Ravasi, Timothy cc
    Tan, K.
    Ideker, T.
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Red Sea Research Center (RSRC)
    Date
    2010-10-26
    Online Publication Date
    2010-10-26
    Print Publication Date
    2010-12-01
    Permanent link to this record
    http://hdl.handle.net/10754/555797
    
    Metadata
    Show full item record
    Abstract
    Transcriptional networks have been shown to evolve very rapidly, prompting questions as to how such changes arise and are tolerated. Recent comparisons of transcriptional networks across species have implicated variations in the cis-acting DNA sequences near genes as the main cause of divergence. What is less clear is how these changes interact with trans-acting changes occurring elsewhere in the genetic circuit. Here, we report the discovery of a system of compensatory trans and cis mutations in the yeast AP-1 transcriptional network that allows for conserved transcriptional regulation despite continued genetic change. We pinpoint a single species, the fungal pathogen Candida glabrata, in which a trans mutation has occurred very recently in a single AP-1 family member, distinguishing it from its Saccharomyces ortholog. Comparison of chromatin immunoprecipitation profiles between Candida and Saccharomyces shows that, despite their different DNA-binding domains, the AP-1 orthologs regulate a conserved block of genes. This conservation is enabled by concomitant changes in the cis-regulatory motifs upstream of each gene. Thus, both trans and cis mutations have perturbed the yeast AP-1 regulatory system in such a way as to compensate for one another. This demonstrates an example of “coevolution” between a DNA-binding transcription factor and its cis-regulatory site, reminiscent of the coevolution of protein binding partners.
    Citation
    Coevolution within a transcriptional network by compensatory trans and cis mutations 2010, 20 (12):1672 Genome Research
    Publisher
    Cold Spring Harbor Laboratory
    Journal
    Genome Research
    DOI
    10.1101/gr.111765.110
    PubMed ID
    20978140
    PubMed Central ID
    PMC2989993
    Additional Links
    http://genome.cshlp.org/cgi/doi/10.1101/gr.111765.110
    ae974a485f413a2113503eed53cd6c53
    10.1101/gr.111765.110
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Red Sea Research Center (RSRC); Bioscience Program; Computational Bioscience Research Center (CBRC)

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