Coevolution within a transcriptional network by compensatory trans and cis mutations
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ArticleAuthors
Kuo, D.Licon, K.
Bandyopadhyay, S.
Chuang, R.
LUO, C.
Catalana, J.
Ravasi, Timothy

Tan, K.
Ideker, T.
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Computational Bioscience Research Center (CBRC)
Red Sea Research Center (RSRC)
Date
2010-10-26Online Publication Date
2010-10-26Print Publication Date
2010-12-01Permanent link to this record
http://hdl.handle.net/10754/555797
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Show full item recordAbstract
Transcriptional networks have been shown to evolve very rapidly, prompting questions as to how such changes arise and are tolerated. Recent comparisons of transcriptional networks across species have implicated variations in the cis-acting DNA sequences near genes as the main cause of divergence. What is less clear is how these changes interact with trans-acting changes occurring elsewhere in the genetic circuit. Here, we report the discovery of a system of compensatory trans and cis mutations in the yeast AP-1 transcriptional network that allows for conserved transcriptional regulation despite continued genetic change. We pinpoint a single species, the fungal pathogen Candida glabrata, in which a trans mutation has occurred very recently in a single AP-1 family member, distinguishing it from its Saccharomyces ortholog. Comparison of chromatin immunoprecipitation profiles between Candida and Saccharomyces shows that, despite their different DNA-binding domains, the AP-1 orthologs regulate a conserved block of genes. This conservation is enabled by concomitant changes in the cis-regulatory motifs upstream of each gene. Thus, both trans and cis mutations have perturbed the yeast AP-1 regulatory system in such a way as to compensate for one another. This demonstrates an example of “coevolution” between a DNA-binding transcription factor and its cis-regulatory site, reminiscent of the coevolution of protein binding partners.Citation
Coevolution within a transcriptional network by compensatory trans and cis mutations 2010, 20 (12):1672 Genome ResearchPublisher
Cold Spring Harbor LaboratoryJournal
Genome ResearchPubMed ID
20978140PubMed Central ID
PMC2989993Additional Links
http://genome.cshlp.org/cgi/doi/10.1101/gr.111765.110ae974a485f413a2113503eed53cd6c53
10.1101/gr.111765.110
Scopus Count
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