Show simple item record

dc.contributor.authorKoser, C. U.
dc.contributor.authorFeuerriegel, S.
dc.contributor.authorSummers, D. K.
dc.contributor.authorArcher, John A.C.
dc.contributor.authorNiemann, S.
dc.date.accessioned2015-05-18T21:52:32Z
dc.date.available2015-05-18T21:52:32Z
dc.date.issued2012-09-24
dc.identifier.citationImportance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistance 2012, 56 (12):6080 Antimicrobial Agents and Chemotherapy
dc.identifier.issn0066-4804
dc.identifier.issn1098-6596
dc.identifier.pmid23006760
dc.identifier.doi10.1128/AAC.01641-12
dc.identifier.urihttp://hdl.handle.net/10754/554104
dc.description.abstractDespite being genetically monomorphic, the limited genetic diversity within the Mycobacterium tuberculosis complex (MTBC) has practical consequences for molecular methods for drug susceptibility testing and for the use of current antibiotics and those in clinical trials. It renders some representatives of MTBC intrinsically resistant against one or multiple antibiotics and affects the spectrum and consequences of resistance mutations selected for during treatment. Moreover, neutral or silent changes within genes responsible for drug resistance can cause false-positive results with hybridization-based assays, which have been recently introduced to replace slower phenotypic methods. We discuss the consequences of these findings and propose concrete steps to rigorously assess the genetic diversity of MTBC to support ongoing clinical trials.
dc.publisherAmerican Society for Microbiology
dc.relation.urlhttp://aac.asm.org/cgi/doi/10.1128/AAC.01641-12
dc.rightsArchived with thanks to Antimicrobial Agents and Chemotherapy
dc.titleImportance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistance
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journalAntimicrobial Agents and Chemotherapy
dc.identifier.pmcidPMC3497208
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom
dc.contributor.institutionHealth Protection Agency, Cambridge, United Kingdom
dc.contributor.institutionMolecular Mycobacteriology, Research Center Borstel, Borstel, Germany
dc.contributor.institutionDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom
kaust.personArcher, John A.C.
refterms.dateFOA2018-06-14T07:50:48Z
dc.date.published-online2012-09-24
dc.date.published-print2012-12


Files in this item

Thumbnail
Name:
Antimicrob. Agents Chemother.-2012-Köser-6080-7.pdf
Size:
205.8Kb
Format:
PDF
Description:
Main article

This item appears in the following Collection(s)

Show simple item record