Type
ArticleKAUST Department
Computational Bioscience Research Center (CBRC)Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Date
2015-05-11Online Publication Date
2015-05-11Print Publication Date
2015Permanent link to this record
http://hdl.handle.net/10754/552988
Metadata
Show full item recordAbstract
Functional magnetic resonance imaging (fMRI) allows the mapping of the brain activation through measurements of the Blood Oxygenation Level Dependent (BOLD) contrast. The characterization of the pathway from the input stimulus to the output BOLD signal requires the selection of an adequate hemodynamic model and the satisfaction of some specific conditions while conducting the experiment and calibrating the model. This paper, focuses on the identifiability of the Balloon hemodynamic model. By identifiability, we mean the ability to estimate accurately the model parameters given the input and the output measurement. Previous studies of the Balloon model have somehow added knowledge either by choosing prior distributions for the parameters, freezing some of them, or looking for the solution as a projection on a natural basis of some vector space. In these studies, the identification was generally assessed using event-related paradigms. This paper justifies the reasons behind the need of adding knowledge, choosing certain paradigms, and completing the few existing identifiability studies through a global sensitivity analysis of the Balloon model in the case of blocked design experiment.Citation
A Sensitivity Analysis of fMRI Balloon Model 2015, 2015:1 Computational and Mathematical Methods in MedicinePublisher
Hindawi LimitedPubMed ID
26078776PubMed Central ID
PMC4442414Additional Links
http://www.hindawi.com/journals/cmmm/2015/425475/ae974a485f413a2113503eed53cd6c53
10.1155/2015/425475
Scopus Count
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