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dc.contributor.authorGiouroudi, Ioanna
dc.contributor.authorvan den Driesche, Sander
dc.contributor.authorKosel, Jürgen
dc.contributor.authorGrössinger, Roland
dc.contributor.authorVellekoop, Michael J.
dc.date.accessioned2015-05-14T07:07:11Z
dc.date.available2015-05-14T07:07:11Z
dc.date.issued2011-03-24
dc.identifier.citationOn-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid 2011, 109 (7):07B304 Journal of Applied Physics
dc.identifier.issn00218979
dc.identifier.doi10.1063/1.3556952
dc.identifier.urihttp://hdl.handle.net/10754/552757
dc.description.abstractA biosensing principle utilizing the motion of suspended magnetic microparticles in a microfluidic system is presented. The system utilizes the innovative concept of the velocity dependence of magnetic microparticles (MPs) due to their volumetric change when analyte is attached to their surface via antibody–antigen binding. When the magnetic microparticles are attracted by a magnetic field within a microfluidic channel their velocity depends on the presence of analyte. Specifically, their velocity decreases drastically when the magnetic microparticles are covered by (nonmagnetic) analyte (LMPs) due to the increased drag force in the opposite direction to that of the magnetic force. Experiments were carried out as a proof of concept. A promising 52% decrease in the velocity of the LMPs in comparison to that of the MPs was measured when both of them were accelerated inside a microfluidic channel using an external permanent magnet. The presented biosensing methodology offers a compact and integrated solution for a new kind of on-chip analysis with potentially high sensitivity and shorter acquisition time than conventional laboratory based systems.
dc.publisherAIP Publishing
dc.relation.urlhttp://scitation.aip.org/content/aip/journal/jap/109/7/10.1063/1.3556952
dc.rightsArchived with thanks to Journal of Applied Physics
dc.titleOn-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid
dc.typeArticle
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSensing, Magnetism and Microsystems Lab
dc.identifier.journalJournal of Applied Physics
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionInstitute of Sensor and Actuator Systems, Vienna University of Technology, 1040, Vienna, Austria
dc.contributor.institutionInstitute of Solid State Physics, Vienna University of Technology, 1040, Vienna, Austria
kaust.personKosel, Jürgen
refterms.dateFOA2018-06-14T06:19:50Z
dc.date.published-online2011-03-24
dc.date.published-print2011-04


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