On-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid
Type
ArticleAuthors
Giouroudi, Ioannavan den Driesche, Sander
Kosel, Jürgen

Grössinger, Roland
Vellekoop, Michael J.
KAUST Department
Electrical Engineering ProgramPhysical Science and Engineering (PSE) Division
Sensing, Magnetism and Microsystems Lab
Date
2011-03-24Online Publication Date
2011-03-24Print Publication Date
2011-04Permanent link to this record
http://hdl.handle.net/10754/552757
Metadata
Show full item recordAbstract
A biosensing principle utilizing the motion of suspended magnetic microparticles in a microfluidic system is presented. The system utilizes the innovative concept of the velocity dependence of magnetic microparticles (MPs) due to their volumetric change when analyte is attached to their surface via antibody–antigen binding. When the magnetic microparticles are attracted by a magnetic field within a microfluidic channel their velocity depends on the presence of analyte. Specifically, their velocity decreases drastically when the magnetic microparticles are covered by (nonmagnetic) analyte (LMPs) due to the increased drag force in the opposite direction to that of the magnetic force. Experiments were carried out as a proof of concept. A promising 52% decrease in the velocity of the LMPs in comparison to that of the MPs was measured when both of them were accelerated inside a microfluidic channel using an external permanent magnet. The presented biosensing methodology offers a compact and integrated solution for a new kind of on-chip analysis with potentially high sensitivity and shorter acquisition time than conventional laboratory based systems.Citation
On-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid 2011, 109 (7):07B304 Journal of Applied PhysicsPublisher
AIP PublishingJournal
Journal of Applied Physicsae974a485f413a2113503eed53cd6c53
10.1063/1.3556952