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    On-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid

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    Type
    Article
    Authors
    Giouroudi, Ioanna
    van den Driesche, Sander
    Kosel, Jürgen cc
    Grössinger, Roland
    Vellekoop, Michael J.
    KAUST Department
    Electrical Engineering Program
    Physical Science and Engineering (PSE) Division
    Sensing, Magnetism and Microsystems Lab
    Date
    2011-03-24
    Online Publication Date
    2011-03-24
    Print Publication Date
    2011-04
    Permanent link to this record
    http://hdl.handle.net/10754/552757
    
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    Abstract
    A biosensing principle utilizing the motion of suspended magnetic microparticles in a microfluidic system is presented. The system utilizes the innovative concept of the velocity dependence of magnetic microparticles (MPs) due to their volumetric change when analyte is attached to their surface via antibody–antigen binding. When the magnetic microparticles are attracted by a magnetic field within a microfluidic channel their velocity depends on the presence of analyte. Specifically, their velocity decreases drastically when the magnetic microparticles are covered by (nonmagnetic) analyte (LMPs) due to the increased drag force in the opposite direction to that of the magnetic force. Experiments were carried out as a proof of concept. A promising 52% decrease in the velocity of the LMPs in comparison to that of the MPs was measured when both of them were accelerated inside a microfluidic channel using an external permanent magnet. The presented biosensing methodology offers a compact and integrated solution for a new kind of on-chip analysis with potentially high sensitivity and shorter acquisition time than conventional laboratory based systems.
    Citation
    On-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid 2011, 109 (7):07B304 Journal of Applied Physics
    Publisher
    AIP Publishing
    Journal
    Journal of Applied Physics
    DOI
    10.1063/1.3556952
    Additional Links
    http://scitation.aip.org/content/aip/journal/jap/109/7/10.1063/1.3556952
    ae974a485f413a2113503eed53cd6c53
    10.1063/1.3556952
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab

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