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dc.contributor.authorGiouroudi, Ioanna
dc.contributor.authorDriesche, Sander van den
dc.contributor.authorKosel, Jürgen
dc.date.accessioned2015-05-10T14:18:37Z
dc.date.available2015-05-10T14:18:37Z
dc.date.issued2010-10-26
dc.identifier.citationBiosensing utilizing the motion of magnetic microparticles in a microfluidic system 2010, 5:824 Procedia Engineering
dc.identifier.issn18777058
dc.identifier.doi10.1016/j.proeng.2010.09.235
dc.identifier.urihttp://hdl.handle.net/10754/552525
dc.description.abstractThe study for the design of a compact and inexpensive biosensing device, which can be operated either by primary care personnel or by patients as opposed to skilled operators, is presented. The main parts of the proposed device are a microfluidic channel, permanent magnets and functionalized magnetic microparticles. The innovative aspect of the proposed biosensing method is that it utilizes the volumetric increase of magnetic microparticles when analyte binds to their surface. Their velocity decreases drastically when they are accelerated by an externally applied magnetic force within a microfluidic channel. This effect is utilized to detect the presence of analyte e.g. microbes. Analytical calculations showed that a decrease in velocity of approximately 23% can be achieved due to the volumetric change of a magnetic microparticle of View the MathML source1μm diameter when HIV virions of approximately View the MathML source0,135μm are bound to its surface and by keeping its magnetic properties the same. Preliminary experiments were carried out utilizing superparamagnetic microparticles coated with streptavidin and polystyrene microparticles coated with biotin.
dc.publisherElsevier BV
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S1877705810007824
dc.rightsArchived with thanks to Procedia Engineering. http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectMicrofluidics
dc.subjectMagnetic microparticles
dc.subjectBiosensors
dc.subjectOn chip
dc.titleBiosensing utilizing the motion of magnetic microparticles in a microfluidic system
dc.typeConference Paper
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.identifier.journalProcedia Engineering
dc.conference.date2010-09-05 to 2010-09-08
dc.conference.name24th Eurosensors Conference
dc.conference.locationLinz, AUT
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionInstitute of Sensor and Actuator Systems, Vienna University of Technology, Gusshausstrasse 27-29/366-ISS, Vienna, 1040, Austria
kaust.personKosel, Jürgen
refterms.dateFOA2018-06-13T13:55:34Z
dc.date.published-online2010-10-26
dc.date.published-print2010


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