Distinct Contributions of Replication and Transcription to Mutation Rate Variation of Human Genomes
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ArticleKAUST Department
Biological and Environmental Science and Engineering (BESE) DivisionCenter for Desert Agriculture
Computational Bioscience Research Center (CBRC)
Date
2012-03-23Online Publication Date
2012-03-23Print Publication Date
2012-02Permanent link to this record
http://hdl.handle.net/10754/552425
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Here, we evaluate the contribution of two major biological processes—DNA replication and transcription—to mutation rate variation in human genomes. Based on analysis of the public human tissue transcriptomics data, high-resolution replicating map of Hela cells and dbSNP data, we present significant correlations between expression breadth, replication time in local regions and SNP density. SNP density of tissue-specific (TS) genes is significantly higher than that of housekeeping (HK) genes. TS genes tend to locate in late-replicating genomic regions and genes in such regions have a higher SNP density compared to those in early-replication regions. In addition, SNP density is found to be positively correlated with expression level among HK genes. We conclude that the process of DNA replication generates stronger mutational pressure than transcription-associated biological processes do, resulting in an increase of mutation rate in TS genes while having weaker effects on HK genes. In contrast, transcription-associated processes are mainly responsible for the accumulation of mutations in highly-expressed HK genes.Citation
Distinct Contributions of Replication and Transcription to Mutation Rate Variation of Human Genomes 2012, 10 (1):4 Genomics, Proteomics & BioinformaticsPublisher
Elsevier BVPubMed ID
22449396Additional Links
http://linkinghub.elsevier.com/retrieve/pii/S1672022911600284ae974a485f413a2113503eed53cd6c53
10.1016/S1672-0229(11)60028-4
Scopus Count
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