Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation
Type
ArticleAuthors
Minocha, ShilpiValloton, Delphine
Ypsilanti, Athena R.
Fiumelli, Hubert

Allen, Elizabeth A.
Yanagawa, Yuchio
Marin, Oscar
Chédotal, Alain
Hornung, Jean-Pierre
Lebrand, Cécile
Date
2015-04-23Online Publication Date
2015-04-23Print Publication Date
2015-12Permanent link to this record
http://hdl.handle.net/10754/551010
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Show full item recordAbstract
Guidepost cells present at and surrounding the midline provide guidance cues that orient the growing axons through commissures. Here we show that the transcription factor Nkx2.1 known to control the specification of GABAergic interneurons also regulates the differentiation of astroglia and polydendrocytes within the mouse anterior commissure (AC). Nkx2.1-positive glia were found to originate from three germinal regions of the ventral telencephalon. Nkx2.1-derived glia were observed in and around the AC region by E14.5. Thereafter, a selective cell ablation strategy showed a synergistic role of Nkx2.1-derived cells, both GABAergic interneurons and astroglia, towards the proper formation of the AC. Finally, our results reveal that the Nkx2.1-regulated cells mediate AC axon guidance through the expression of the repellent cue, Slit2. These results bring forth interesting insights about the spatial and temporal origin of midline telencephalic glia, and highlight the importance of neurons and astroglia towards the formation of midline commissures.Citation
Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation 2015, 6:6887 Nature CommunicationsPublisher
Springer NatureJournal
Nature CommunicationsPubMed ID
25904499PubMed Central ID
PMC4423212Additional Links
http://www.nature.com/doifinder/10.1038/ncomms7887ae974a485f413a2113503eed53cd6c53
10.1038/ncomms7887
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