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    Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation

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    Type
    Article
    Authors
    Minocha, Shilpi
    Valloton, Delphine
    Ypsilanti, Athena R.
    Fiumelli, Hubert cc
    Allen, Elizabeth A.
    Yanagawa, Yuchio
    Marin, Oscar
    Chédotal, Alain
    Hornung, Jean-Pierre
    Lebrand, Cécile
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Date
    2015-04-23
    Online Publication Date
    2015-04-23
    Print Publication Date
    2015-12
    Permanent link to this record
    http://hdl.handle.net/10754/551010
    
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    Abstract
    Guidepost cells present at and surrounding the midline provide guidance cues that orient the growing axons through commissures. Here we show that the transcription factor Nkx2.1 known to control the specification of GABAergic interneurons also regulates the differentiation of astroglia and polydendrocytes within the mouse anterior commissure (AC). Nkx2.1-positive glia were found to originate from three germinal regions of the ventral telencephalon. Nkx2.1-derived glia were observed in and around the AC region by E14.5. Thereafter, a selective cell ablation strategy showed a synergistic role of Nkx2.1-derived cells, both GABAergic interneurons and astroglia, towards the proper formation of the AC. Finally, our results reveal that the Nkx2.1-regulated cells mediate AC axon guidance through the expression of the repellent cue, Slit2. These results bring forth interesting insights about the spatial and temporal origin of midline telencephalic glia, and highlight the importance of neurons and astroglia towards the formation of midline commissures.
    Citation
    Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation 2015, 6:6887 Nature Communications
    Publisher
    Springer Nature
    Journal
    Nature Communications
    DOI
    10.1038/ncomms7887
    PubMed ID
    25904499
    PubMed Central ID
    PMC4423212
    Additional Links
    http://www.nature.com/doifinder/10.1038/ncomms7887
    ae974a485f413a2113503eed53cd6c53
    10.1038/ncomms7887
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division

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