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dc.contributor.authorKarmin, Monika
dc.contributor.authorSaag, Lauri
dc.contributor.authorVicente, Mário
dc.contributor.authorSayres, Melissa A. Wilson
dc.contributor.authorJärve, Mari
dc.contributor.authorTalas, Ulvi Gerst
dc.contributor.authorRootsi, Siiri
dc.contributor.authorIlumäe, Anne-Mai
dc.contributor.authorMägi, Reedik
dc.contributor.authorMitt, Mario
dc.contributor.authorPagani, Luca
dc.contributor.authorPuurand, Tarmo
dc.contributor.authorFaltyskova, Zuzana
dc.contributor.authorClemente, Florian
dc.contributor.authorCardona, Alexia
dc.contributor.authorMetspalu, Ene
dc.contributor.authorSahakyan, Hovhannes
dc.contributor.authorYunusbayev, Bayazit
dc.contributor.authorHudjashov, Georgi
dc.contributor.authorDeGiorgio, Michael
dc.contributor.authorLoogväli, Eva-Liis
dc.contributor.authorEichstaedt, Christina
dc.contributor.authorEelmets, Mikk
dc.contributor.authorChaubey, Gyaneshwer
dc.contributor.authorTambets, Kristiina
dc.contributor.authorLitvinov, Sergei
dc.contributor.authorMormina, Maru
dc.contributor.authorXue, Yali
dc.contributor.authorAyub, Qasim
dc.contributor.authorZoraqi, Grigor
dc.contributor.authorKorneliussen, Thorfinn Sand
dc.contributor.authorAkhatova, Farida
dc.contributor.authorLachance, Joseph
dc.contributor.authorTishkoff, Sarah
dc.contributor.authorMomynaliev, Kuvat
dc.contributor.authorRicaut, François-Xavier
dc.contributor.authorKusuma, Pradiptajati
dc.contributor.authorRazafindrazaka, Harilanto
dc.contributor.authorPierron, Denis
dc.contributor.authorCox, Murray P.
dc.contributor.authorSultana, Gazi Nurun Nahar
dc.contributor.authorWillerslev, Rane
dc.contributor.authorMuller, Craig
dc.contributor.authorWestaway, Michael
dc.contributor.authorLambert, David
dc.contributor.authorSkaro, Vedrana
dc.contributor.authorKovačevic´, Lejla
dc.contributor.authorTurdikulova, Shahlo
dc.contributor.authorDalimova, Dilbar
dc.contributor.authorKhusainova, Rita
dc.contributor.authorTrofimova, Natalya
dc.contributor.authorAkhmetova, Vita
dc.contributor.authorKhidiyatova, Irina
dc.contributor.authorLichman, Daria V.
dc.contributor.authorIsakova, Jainagul
dc.contributor.authorPocheshkhova, Elvira
dc.contributor.authorSabitov, Zhaxylyk
dc.contributor.authorBarashkov, Nikolay A.
dc.contributor.authorNymadawa, Pagbajabyn
dc.contributor.authorMihailov, Evelin
dc.contributor.authorSeng, Joseph Wee Tien
dc.contributor.authorEvseeva, Irina
dc.contributor.authorMigliano, Andrea Bamberg
dc.contributor.authorAbdullah, Syafiq
dc.contributor.authorAndriadze, George
dc.contributor.authorPrimorac, Dragan
dc.contributor.authorAtramentova, Lubov
dc.contributor.authorUtevska, Olga
dc.contributor.authorYepiskoposyan, Levon
dc.contributor.authorMarjanovic´, Damir
dc.contributor.authorKushniarevich, Alena
dc.contributor.authorBehar, Doron M.
dc.contributor.authorGilissen, Christian
dc.contributor.authorVissers, Lisenka
dc.contributor.authorVeltman, Joris A.
dc.contributor.authorBalanovska, Elena
dc.contributor.authorDerenko, Miroslava
dc.contributor.authorMalyarchuk, Boris
dc.contributor.authorMetspalu, Andres
dc.contributor.authorFedorova, Sardana
dc.contributor.authorEriksson, Anders
dc.contributor.authorManica, Andrea
dc.contributor.authorMendez, Fernando L.
dc.contributor.authorKarafet, Tatiana M.
dc.contributor.authorVeeramah, Krishna R.
dc.contributor.authorBradman, Neil
dc.contributor.authorHammer, Michael F.
dc.contributor.authorOsipova, Ludmila P.
dc.contributor.authorBalanovsky, Oleg
dc.contributor.authorKhusnutdinova, Elza K.
dc.contributor.authorJohnsen, Knut
dc.contributor.authorRemm, Maido
dc.contributor.authorThomas, Mark G.
dc.contributor.authorTyler-Smith, Chris
dc.contributor.authorUnderhill, Peter A.
dc.contributor.authorWillerslev, Eske
dc.contributor.authorNielsen, Rasmus
dc.contributor.authorMetspalu, Mait
dc.contributor.authorVillems, Richard
dc.contributor.authorKivisild, Toomas
dc.date.accessioned2015-04-21T14:24:00Z
dc.date.available2015-04-21T14:24:00Z
dc.date.issued2015-03-13
dc.identifier.citationA recent bottleneck of Y chromosome diversity coincides with a global change in culture 2015, 25 (4):459 Genome Research
dc.identifier.issn1088-9051
dc.identifier.issn1549-5469
dc.identifier.pmid25770088
dc.identifier.doi10.1101/gr.186684.114
dc.identifier.urihttp://hdl.handle.net/10754/550413
dc.description.abstractIt is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
dc.publisherCold Spring Harbor Laboratory
dc.relation.urlhttp://genome.cshlp.org/lookup/doi/10.1101/gr.186684.114
dc.rightsThis article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
dc.titleA recent bottleneck of Y chromosome diversity coincides with a global change in culture
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentIntegrative Systems Biology Lab
dc.identifier.journalGenome Research
dc.identifier.pmcidPMC4381518
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionEstonian Biocentre, Tartu, 51010, Estonia
dc.contributor.institutionDepartment of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, 51010, Estonia
dc.contributor.institutionDepartment of Botany, Institute of Ecology and Earth Sciences, University of Tartu, Tartu, 51010, Estonia
dc.contributor.institutionDivision of Biological Anthropology, University of Cambridge, Cambridge, United Kingdom
dc.contributor.institutionDepartment of Integrative Biology, University of California Berkeley, Berkeley, California, USA
dc.contributor.institutionSchool of Life Sciences and The Biodesign Institute, Tempe, Arizona, USA
dc.contributor.institutionDepartment of Bioinformatics, Institute of Molecular and Cell Biology, University of Tartu, Tartu, 51010, Estonia
dc.contributor.institutionEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia
dc.contributor.institutionDepartment of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, 51010, Estonia
dc.contributor.institutionLaboratory of Ethnogenomics, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia
dc.contributor.institutionInstitute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russia
dc.contributor.institutionDepartment of Psychology, University of Auckland, Auckland, 1142, New Zealand
dc.contributor.institutionDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, USA
dc.contributor.institutionDepartment of Applied Social Sciences, University of Winchester, Winchester, United Kingdom
dc.contributor.institutionThe Wellcome Trust Sanger Institute, Hinxton, United Kingdom
dc.contributor.institutionCenter of Molecular Diagnosis and Genetic Research, University Hospital of Obstetrics and Gynecology, Tirana, Albania
dc.contributor.institutionCenter for GeoGenetics, University of Copenhagen, Copenhagen, Denmark
dc.contributor.institutionDepartment of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia
dc.contributor.institutionInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia
dc.contributor.institutionDepartment of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
dc.contributor.institutionSchool of Biology, Georgia Institute of Technology, Atlanta, Georgia, USA
dc.contributor.institutionDepartment of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
dc.contributor.institutionDNcode Laboratories, Moscow, Russia
dc.contributor.institutionEvolutionary Medicine Group, Laboratoire d'Anthropologie Moléculaire et Imagerie de Synthèse, Centre National de la Recherche Scientifique, Université de Toulouse 3, Toulouse, France
dc.contributor.institutionEijkman Institute for Molecular Biology, Jakarta, Indonesia
dc.contributor.institutionStatistics and Bioinformatics Group, Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand
dc.contributor.institutionCentre for Advanced Research in Sciences (CARS), DNA Sequencing Research Laboratory, University of Dhaka, Dhaka, Bangladesh
dc.contributor.institutionArctic Research Centre, Aarhus University, Aarhus, DK-8000, Denmark
dc.contributor.institutionEnvironmental Futures Research Institute, Griffith University, Nathan, Australia
dc.contributor.institutionGenos, DNA Laboratory, Zagreb, Croatia
dc.contributor.institutionUniversity of Osijek, Medical School, Osijek, Croatia
dc.contributor.institutionCentogene AG, Rostock, Germany
dc.contributor.institutionInstitute of Bioorganic Chemistry, Academy of Science, Tashkent, 100143, Uzbekistan
dc.contributor.institutionInstitute of Cytology and Genetics, Novosibirsk, Russia
dc.contributor.institutionInstitute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan
dc.contributor.institutionKuban State Medical University, Krasnodar, Russia
dc.contributor.institutionL. N. Gumilyov Eurasian National University, Astana, Kazakhstan
dc.contributor.institutionCenter for Life Sciences, Nazarbayev University, Astana, Kazakhstan
dc.contributor.institutionDepartment of Molecular Genetics, Yakut Scientific Centre of Complex Medical Problems, Yakutsk, Russia
dc.contributor.institutionLaboratory of Molecular Biology, Institute of Natural Sciences, M. K. Ammosov North-Eastern Federal University, Yakutsk, Russia
dc.contributor.institutionMongolian Academy of Medical Sciences, Ulaanbaatar, Mongolia
dc.contributor.institutionNational Cancer Centre Singapore, Singapore
dc.contributor.institutionNorthern State Medical University, Arkhangelsk, Russia
dc.contributor.institutionAnthony Nolan, London, UK
dc.contributor.institutionDepartment of Anthropology, University College London, London, United Kingdom
dc.contributor.institutionRIPAS Hospital, Bandar Seri Begawan, Brunei
dc.contributor.institutionScientific-Research Center of the Caucasian Ethnic Groups, St. Andrews Georgian University, Tbilisi, Georgia
dc.contributor.institutionSt. Catherine Specialty Hospital, Zabok, Croatia
dc.contributor.institutionEberly College of Science, Pennsylvania State University, University Park, Pennsylvania, USA
dc.contributor.institutionUniversity of Split, Medical School, Split, Croatia
dc.contributor.institutionV. N. Karazin Kharkiv National University, Kharkiv, Ukraine
dc.contributor.institutionDepartment of Genetics and Bioengineering, Faculty of Engineering and Information Technologies, International Burch University, Sarajevo, Bosnia and Herzegovina
dc.contributor.institutionInstitute of Genetics and Cytology, National Academy of Sciences, Minsk, Belarus
dc.contributor.institutionDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands
dc.contributor.institutionResearch Centre for Medical Genetics, Russian Academy of Sciences, Moscow, Russia
dc.contributor.institutionGenetics Laboratory, Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, Russia
dc.contributor.institutionDepartment of Zoology, University of Cambridge, Cambridge, United Kingdom
dc.contributor.institutionDepartment of Genetics, Stanford University School of Medicine, Stanford, California, USA
dc.contributor.institutionARL Division of Biotechnology, University of Arizona, Tucson, Arizona, USA
dc.contributor.institutionDepartment of Ecology and Evolution, Stony Brook University, Stony Brook, New York, USA
dc.contributor.institutionThe Henry Stewart Group, London, United Kingdom
dc.contributor.institutionVavilov Institute for General Genetics, Russian Academy of Sciences, Moscow, Russia
dc.contributor.institutionUniversity Hospital of North Norway, Tromsøe, Norway
dc.contributor.institutionResearch Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
dc.contributor.institutionEstonian Academy of Sciences, Tallinn, Estonia
kaust.personEriksson, Anders
refterms.dateFOA2015-10-30T00:00:00Z
dc.date.published-online2015-03-13
dc.date.published-print2015-04


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