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    A recent bottleneck of Y chromosome diversity coincides with a global change in culture

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    Type
    Article
    Authors
    Karmin, Monika
    Saag, Lauri
    Vicente, Mário
    Sayres, Melissa A. Wilson
    Järve, Mari
    Talas, Ulvi Gerst
    Rootsi, Siiri
    Ilumäe, Anne-Mai
    Mägi, Reedik
    Mitt, Mario
    Pagani, Luca
    Puurand, Tarmo
    Faltyskova, Zuzana
    Clemente, Florian
    Cardona, Alexia
    Metspalu, Ene
    Sahakyan, Hovhannes
    Yunusbayev, Bayazit
    Hudjashov, Georgi
    DeGiorgio, Michael
    Loogväli, Eva-Liis
    Eichstaedt, Christina
    Eelmets, Mikk
    Chaubey, Gyaneshwer
    Tambets, Kristiina
    Litvinov, Sergei
    Mormina, Maru
    Xue, Yali
    Ayub, Qasim
    Zoraqi, Grigor
    Korneliussen, Thorfinn Sand
    Akhatova, Farida
    Lachance, Joseph
    Tishkoff, Sarah
    Momynaliev, Kuvat
    Ricaut, François-Xavier
    Kusuma, Pradiptajati
    Razafindrazaka, Harilanto
    Pierron, Denis
    Cox, Murray P.
    Sultana, Gazi Nurun Nahar
    Willerslev, Rane
    Muller, Craig
    Westaway, Michael
    Lambert, David
    Skaro, Vedrana
    Kovačevic´, Lejla
    Turdikulova, Shahlo
    Dalimova, Dilbar
    Khusainova, Rita
    Trofimova, Natalya
    Akhmetova, Vita
    Khidiyatova, Irina
    Lichman, Daria V.
    Isakova, Jainagul
    Pocheshkhova, Elvira
    Sabitov, Zhaxylyk
    Barashkov, Nikolay A.
    Nymadawa, Pagbajabyn
    Mihailov, Evelin
    Seng, Joseph Wee Tien
    Evseeva, Irina
    Migliano, Andrea Bamberg
    Abdullah, Syafiq
    Andriadze, George
    Primorac, Dragan
    Atramentova, Lubov
    Utevska, Olga
    Yepiskoposyan, Levon
    Marjanovic´, Damir
    Kushniarevich, Alena
    Behar, Doron M.
    Gilissen, Christian
    Vissers, Lisenka
    Veltman, Joris A.
    Balanovska, Elena
    Derenko, Miroslava
    Malyarchuk, Boris
    Metspalu, Andres
    Fedorova, Sardana
    Eriksson, Anders cc
    Manica, Andrea
    Mendez, Fernando L.
    Karafet, Tatiana M.
    Veeramah, Krishna R.
    Bradman, Neil
    Hammer, Michael F.
    Osipova, Ludmila P.
    Balanovsky, Oleg
    Khusnutdinova, Elza K.
    Johnsen, Knut
    Remm, Maido
    Thomas, Mark G.
    Tyler-Smith, Chris
    Underhill, Peter A.
    Willerslev, Eske
    Nielsen, Rasmus
    Metspalu, Mait
    Villems, Richard
    Kivisild, Toomas
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Integrative Systems Biology Lab
    Date
    2015-03-13
    Online Publication Date
    2015-03-13
    Print Publication Date
    2015-04
    Permanent link to this record
    http://hdl.handle.net/10754/550413
    
    Metadata
    Show full item record
    Abstract
    It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
    Citation
    A recent bottleneck of Y chromosome diversity coincides with a global change in culture 2015, 25 (4):459 Genome Research
    Publisher
    Cold Spring Harbor Laboratory
    Journal
    Genome Research
    DOI
    10.1101/gr.186684.114
    PubMed ID
    25770088
    PubMed Central ID
    PMC4381518
    Additional Links
    http://genome.cshlp.org/lookup/doi/10.1101/gr.186684.114
    ae974a485f413a2113503eed53cd6c53
    10.1101/gr.186684.114
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division

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