Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles

Wang, Xiang; Li, Shunbo; Wang, Limu; Yi, Xin; Hui, Yu Sanna; Qin, Jianhua; Wen, Weijia

Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles

Files

p5-wang.pdf (1.68 MB)

Type

Article

Authors

Wang, Xiang
Li, Shunbo
Wang, Limu
Yi, Xin
Hui, Yu Sanna
Qin, Jianhua
Wen, Weijia

KAUST Department

KAUST-HKUST Joint Micro/Nanofluidic Laboratory

Online Publication Date

2013-09-25

Print Publication Date

2013

Date

2013-09-25

Abstract

We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.

Citation

Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles 2013, 2013:1 Journal of Nanomaterials