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    Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles

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    Type
    Article
    Authors
    Wang, Xiang
    Li, Shunbo
    Wang, Limu
    Yi, Xin
    Hui, Yu Sanna
    Qin, Jianhua
    Wen, Weijia
    KAUST Department
    KAUST-HKUST Joint Micro/Nanofluidic Laboratory
    Date
    2013-09-25
    Online Publication Date
    2013-09-25
    Print Publication Date
    2013
    Permanent link to this record
    http://hdl.handle.net/10754/550220
    
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    Abstract
    We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.
    Citation
    Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles 2013, 2013:1 Journal of Nanomaterials
    Publisher
    Hindawi Limited
    Journal
    Journal of Nanomaterials
    DOI
    10.1155/2013/864584
    Additional Links
    http://www.hindawi.com/journals/jnm/2013/864584/
    ae974a485f413a2113503eed53cd6c53
    10.1155/2013/864584
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