Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles
Type
ArticleKAUST Department
KAUST-HKUST Joint Micro/Nanofluidic LaboratoryDate
2013-09-25Online Publication Date
2013-09-25Print Publication Date
2013Permanent link to this record
http://hdl.handle.net/10754/550220
Metadata
Show full item recordAbstract
We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.Citation
Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles 2013, 2013:1 Journal of NanomaterialsPublisher
Hindawi LimitedJournal
Journal of NanomaterialsAdditional Links
http://www.hindawi.com/journals/jnm/2013/864584/ae974a485f413a2113503eed53cd6c53
10.1155/2013/864584