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dc.contributor.authorZhang, Yi-Fan
dc.contributor.authorXiao, Kang
dc.contributor.authorChandramouli, Kondethimmanahalli
dc.contributor.authorXu, Ying
dc.contributor.authorPan, Ke
dc.contributor.authorWang, Wen-Xiong
dc.contributor.authorQian, Pei-Yuan
dc.date.accessioned2015-04-16T14:02:34Z
dc.date.available2015-04-16T14:02:34Z
dc.date.issued2011-08-29
dc.identifier.citationAcute Toxicity of the Antifouling Compound Butenolide in Non-Target Organisms 2011, 6 (8):e23803 PLoS ONE
dc.identifier.issn1932-6203
dc.identifier.pmid21897857
dc.identifier.doi10.1371/journal.pone.0023803
dc.identifier.urihttp://hdl.handle.net/10754/550219
dc.description.abstractButenolide [5-octylfuran-2(5H)-one] is a recently discovered and very promising anti-marine-fouling compound. In this study, the acute toxicity of butenolide was assessed in several non-target organisms, including micro algae, crustaceans, and fish. Results were compared with previously reported results on the effective concentrations used on fouling (target) organisms. According to OECD's guideline, the predicted no effect concentration (PNEC) was 0.168 µg l^(−1), which was among one of the highest in representative new biocides. Mechanistically, the phenotype of butenolide-treated Danio rerio (zebrafish) embryos was similar to the phenotype of the pro-caspase-3 over-expression mutant with pericardial edema, small eyes, small brains, and increased numbers of apoptotic cells in the bodies of zebrafish embryos. Butenolide also induced apoptosis in HeLa cells, with the activation of c-Jun N-terminal kinases (JNK), Bcl-2 family proteins, and caspases and proteasomes/lysosomes involved in this process. This is the first detailed toxicity and toxicology study on this antifouling compound.
dc.description.sponsorshipThis work was supported by an award [SA-C0040/UK-C0016] from the King Abdullah University of Science and Technology (http://www.kaust.edu.sa/) and grants from the Research Grants Council of HKSAR (http://www.ugc.edu.hk/eng/rgc/index.htm) [N_HKUST602/09, AoE/P-04/04-2-II] to PY Qian. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.publisherPublic Library of Science (PLoS)
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0023803
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.titleAcute Toxicity of the Antifouling Compound Butenolide in Non-Target Organisms
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journalPLoS ONE
dc.identifier.pmcidPMC3163639
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDivision of Life Science, Hong Kong University of Division of Life Science, Hong Kong University of Science and Technology, Hong Kong, SAR, ChinaScience and Technology, Hong Kong SAR, China
kaust.personZhang, Yi-Fan
kaust.personXiao, Kang
kaust.personChandramouli, Kondethimmanahalli
kaust.personXu, Ying
kaust.personQian, Pei-Yuan
kaust.grant.numberSA-C0040
kaust.grant.numberUK-C0016
kaust.grant.programKAUST Global Collaborative Research Program
refterms.dateFOA2018-06-13T16:52:46Z


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