Structural Molecular Components of Septate Junctions in Cnidarians Point to the Origin of Epithelial Junctions in Eukaryotes
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Type
ArticleAuthors
Ganot, P.Zoccola, D.
Tambutte, E.
Voolstra, Christian R.

Aranda, Manuel

Allemand, D.
Tambutte, S.
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionMarine Science Program
Red Sea Research Center (RSRC)
Reef Genomics Lab
Date
2014-09-21Online Publication Date
2014-09-21Print Publication Date
2015-01Permanent link to this record
http://hdl.handle.net/10754/550141
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Septate junctions (SJs) insure barrier properties and control paracellular diffusion of solutes across epithelia in invertebrates. However, the origin and evolution of their molecular constituents in Metazoa have not been firmly established. Here, we investigated the genomes of early branching metazoan representatives to reconstruct the phylogeny of the molecular components of SJs. Although Claudins and SJ cytoplasmic adaptor components appeared successively throughout metazoan evolution, the structural components of SJs arose at the time of Placozoa/Cnidaria/Bilateria radiation. We also show that in the scleractinian coral Stylophora pistillata, the structural SJ component Neurexin IV colocalizes with the cortical actin network at the apical border of the cells, at the place of SJs. We propose a model for SJ components in Cnidaria. Moreover, our study reveals an unanticipated diversity of SJ structural component variants in cnidarians. This diversity correlates with gene-specific expression in calcifying and noncalcifying tissues, suggesting specific paracellular pathways across the cell layers of these diploblastic animals.Citation
Structural Molecular Components of Septate Junctions in Cnidarians Point to the Origin of Epithelial Junctions in Eukaryotes 2014, 32 (1):44 Molecular Biology and EvolutionPublisher
Oxford University Press (OUP)Journal
Molecular Biology and EvolutionPubMed ID
25246700Additional Links
http://mbe.oxfordjournals.org/cgi/doi/10.1093/molbev/msu265ae974a485f413a2113503eed53cd6c53
10.1093/molbev/msu265
Scopus Count
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