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    Structural Molecular Components of Septate Junctions in Cnidarians Point to the Origin of Epithelial Junctions in Eukaryotes

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    Type
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    Authors
    Ganot, P.
    Zoccola, D.
    Tambutte, E.
    Voolstra, Christian R. cc
    Aranda, Manuel cc
    Allemand, D.
    Tambutte, S.
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Marine Science Program
    Red Sea Research Center (RSRC)
    Reef Genomics Lab
    Date
    2014-09-21
    Online Publication Date
    2014-09-21
    Print Publication Date
    2015-01
    Permanent link to this record
    http://hdl.handle.net/10754/550141
    
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    Abstract
    Septate junctions (SJs) insure barrier properties and control paracellular diffusion of solutes across epithelia in invertebrates. However, the origin and evolution of their molecular constituents in Metazoa have not been firmly established. Here, we investigated the genomes of early branching metazoan representatives to reconstruct the phylogeny of the molecular components of SJs. Although Claudins and SJ cytoplasmic adaptor components appeared successively throughout metazoan evolution, the structural components of SJs arose at the time of Placozoa/Cnidaria/Bilateria radiation. We also show that in the scleractinian coral Stylophora pistillata, the structural SJ component Neurexin IV colocalizes with the cortical actin network at the apical border of the cells, at the place of SJs. We propose a model for SJ components in Cnidaria. Moreover, our study reveals an unanticipated diversity of SJ structural component variants in cnidarians. This diversity correlates with gene-specific expression in calcifying and noncalcifying tissues, suggesting specific paracellular pathways across the cell layers of these diploblastic animals.
    Citation
    Structural Molecular Components of Septate Junctions in Cnidarians Point to the Origin of Epithelial Junctions in Eukaryotes 2014, 32 (1):44 Molecular Biology and Evolution
    Publisher
    Oxford University Press (OUP)
    Journal
    Molecular Biology and Evolution
    DOI
    10.1093/molbev/msu265
    PubMed ID
    25246700
    Additional Links
    http://mbe.oxfordjournals.org/cgi/doi/10.1093/molbev/msu265
    ae974a485f413a2113503eed53cd6c53
    10.1093/molbev/msu265
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Red Sea Research Center (RSRC); Marine Science Program; Reef Genomics, part of the Global Ocean Genome Project

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