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dc.contributor.authorAltaf, Muhammad
dc.contributor.authorMonim-ul-Mehboob, M.
dc.contributor.authorSeliman, Adam A.A.
dc.contributor.authorSohail, Manzar
dc.contributor.authorWazeer, Mohammed I.M.
dc.contributor.authorIsab, Anvarhusein A.
dc.contributor.authorLi, L.
dc.contributor.authorDhuna, V.
dc.contributor.authorBhatia, G.
dc.contributor.authorDhuna, K.
dc.date.accessioned2015-04-06T09:18:03Z
dc.date.available2015-04-06T09:18:03Z
dc.date.issued2015-03-10
dc.identifier.citationSynthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands 2015 European Journal of Medicinal Chemistry
dc.identifier.issn02235234
dc.identifier.pmid25841201
dc.identifier.doi10.1016/j.ejmech.2015.03.019
dc.identifier.urihttp://hdl.handle.net/10754/348543
dc.description.abstractTwo new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested.
dc.publisherElsevier BV
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0223523415001865
dc.rightsArchived with thanks to European Journal of Medicinal Chemistry. Copyright © 2015 Published by Elsevier Masson SAS
dc.titleSynthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands
dc.typeArticle
dc.contributor.departmentKing Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900 Jeddah, Saudi Arabia
dc.identifier.journalEuropean Journal of Medicinal Chemistry
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia
dc.contributor.institutionCenter of Excellence in Nanotechnology, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia
dc.contributor.institutionDept. of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India
dc.contributor.institutionDepartment of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India
kaust.personLi, L.
dc.relation.issupplementedbyDOI:10.5517/cc10s745
dc.relation.issupplementedbyDOI:10.5517/cc10s734
refterms.dateFOA2017-03-10T00:00:00Z
display.relations<b> Is Supplemented By:</b> <br/> <ul> <li><i>[Dataset]</i> <br/> . DOI: <a href="https://doi.org/10.5517/cc10s745">10.5517/cc10s745</a> HANDLE: <a href="http://hdl.handle.net/10754/663529">10754/663529</a></li></ul><b> Is Supplemented By:</b> <br/> <ul> <li><i>[Dataset]</i> <br/> . DOI: <a href="https://doi.org/10.5517/cc10s734">10.5517/cc10s734</a> HANDLE: <a href="http://hdl.handle.net/10754/664290">10754/664290</a></li></ul>
dc.date.published-online2015-03-10
dc.date.published-print2015-05


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