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dc.contributor.authorReid, Adam J.
dc.contributor.authorBlake, Damer P.
dc.contributor.authorAnsari, Hifzur R.
dc.contributor.authorBillington, Karen
dc.contributor.authorBrowne, Hilary P.
dc.contributor.authorBryant, Josephine
dc.contributor.authorDunn, Matt
dc.contributor.authorHung, Stacy S.
dc.contributor.authorKawahara, Fumiya
dc.contributor.authorMiranda-Saavedra, Diego
dc.contributor.authorMalas, Tareq B.
dc.contributor.authorMourier, Tobias
dc.contributor.authorNaghra, Hardeep
dc.contributor.authorNair, Mridul
dc.contributor.authorOtto, Thomas D.
dc.contributor.authorRawlings, Neil D.
dc.contributor.authorRivailler, Pierre
dc.contributor.authorSanchez-Flores, Alejandro
dc.contributor.authorSanders, Mandy
dc.contributor.authorSubramaniam, Chandra
dc.contributor.authorTay, Yea-Ling
dc.contributor.authorWoo, Yong
dc.contributor.authorWu, Xikun
dc.contributor.authorBarrell, Bart
dc.contributor.authorDear, Paul H.
dc.contributor.authorDoerig, Christian
dc.contributor.authorGruber, Arthur
dc.contributor.authorIvens, Alasdair C.
dc.contributor.authorParkinson, John
dc.contributor.authorRajandream, Marie-Adèle
dc.contributor.authorShirley, Martin W.
dc.contributor.authorWan, Kiew-Lian
dc.contributor.authorBerriman, Matthew
dc.contributor.authorTomley, Fiona M.
dc.contributor.authorPain, Arnab
dc.date.accessioned2015-03-23T08:20:42Z
dc.date.available2015-03-23T08:20:42Z
dc.date.issued2014-10
dc.identifier.citationGenomic analysis of the causative agents of coccidiosis in domestic chickens 2014, 24 (10):1676 Genome Research
dc.identifier.issn1088-9051
dc.identifier.issn1549-5469
dc.identifier.pmid25015382
dc.identifier.doi10.1101/gr.168955.113
dc.identifier.urihttp://hdl.handle.net/10754/346998
dc.description.abstractGlobal production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.
dc.publisherCold Spring Harbor Laboratory Press
dc.relation.urlhttp://genome.cshlp.org/lookup/doi/10.1101/gr.168955.113
dc.rightsThis article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
dc.titleGenomic analysis of the causative agents of coccidiosis in domestic chickens
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journalGenome Research
dc.identifier.pmcidPMC4199364
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionWellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
dc.contributor.institutionRoyal Veterinary College, North Mymms, Hertfordshire AL9 7TA, United Kingdom
dc.contributor.institutionThe Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom
dc.contributor.institutionProgram in Molecular Structure and Function, Hospital for Sick Children and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
dc.contributor.institutionNippon Institute for Biological Science, Ome, Tokyo 198-0024, Japan
dc.contributor.institutionFibrosis Laboratories, Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
dc.contributor.institutionCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark
dc.contributor.institutionSchool of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
dc.contributor.institutionEuropean Bioinformatics Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
dc.contributor.institutionDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
dc.contributor.institutionUnidad Universitaria de Apoyo Bioinformático, Institute of Biotechnology, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210, Mexico
dc.contributor.institutionSchool of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor DE, Malaysia
dc.contributor.institutionMalaysia Genome Institute, Jalan Bangi, 43000 Kajang, Selangor DE, Malaysia
dc.contributor.institutionAmgen Limited, Uxbridge UB8 1DH, United Kingdom
dc.contributor.institutionMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
dc.contributor.institutionDepartment of Microbiology, Monash University, Clayton VIC 3800, Australia
dc.contributor.institutionDepartament of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil
dc.contributor.institutionCentre for Immunity, Infection and Evolution, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
dc.contributor.institutionThe Pirbright Institute, Pirbright Laboratory, Pirbright, Surrey GU24 0NF, United Kingdom
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personAnsari, Hifzur Rahman
kaust.personMalas, Tareq Majed Yasin
kaust.personNair, Mridul
kaust.personWoo, Yong
kaust.personPain, Arnab
refterms.dateFOA2018-06-14T07:30:39Z


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