Genomic analysis of the causative agents of coccidiosis in domestic chickens
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Type
ArticleAuthors
Reid, Adam J.Blake, Damer P.
Ansari, Hifzur Rahman

Billington, Karen
Browne, Hilary P.
Bryant, Josephine
Dunn, Matt
Hung, Stacy S.
Kawahara, Fumiya
Miranda-Saavedra, Diego
Malas, Tareq Majed Yasin

Mourier, Tobias
Naghra, Hardeep
Nair, Mridul
Otto, Thomas D.
Rawlings, Neil D.
Rivailler, Pierre
Sanchez-Flores, Alejandro
Sanders, Mandy
Subramaniam, Chandra
Tay, Yea-Ling
Woo, Yong
Wu, Xikun
Barrell, Bart
Dear, Paul H.
Doerig, Christian
Gruber, Arthur
Ivens, Alasdair C.
Parkinson, John
Rajandream, Marie-Adèle
Shirley, Martin W.
Wan, Kiew-Lian
Berriman, Matthew
Tomley, Fiona M.
Pain, Arnab

KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Computational Bioscience Research Center (CBRC)
Computer Science Program
Pathogen Genomics Laboratory
Date
2014-07-11Online Publication Date
2014-07-11Print Publication Date
2014-10Permanent link to this record
http://hdl.handle.net/10754/346998
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Show full item recordAbstract
Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.Citation
Genomic analysis of the causative agents of coccidiosis in domestic chickens 2014, 24 (10):1676 Genome ResearchPublisher
Cold Spring Harbor LaboratoryJournal
Genome ResearchPubMed ID
25015382PubMed Central ID
PMC4199364Additional Links
http://genome.cshlp.org/lookup/doi/10.1101/gr.168955.113ae974a485f413a2113503eed53cd6c53
10.1101/gr.168955.113
Scopus Count
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