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dc.contributor.authorContreras, Maria F.
dc.contributor.authorSougrat, Rachid
dc.contributor.authorZaher, Amir Omar
dc.contributor.authorRavasi, Timothy
dc.contributor.authorKosel, Jürgen
dc.date.accessioned2015-03-23T08:19:38Z
dc.date.available2015-03-23T08:19:38Z
dc.date.issued2015-03
dc.identifier.citationNon-chemotoxic induction of cancer cell death using magnetic nanowires 2015:2141 International Journal of Nanomedicine
dc.identifier.issn1178-2013
dc.identifier.pmid25834430
dc.identifier.doi10.2147/IJN.S77081
dc.identifier.urihttp://hdl.handle.net/10754/346981
dc.description.abstractIn this paper, we show that magnetic nanowires with weak magnetic fields and low frequencies can induce cell death via a mechanism that does not involve heat production. We incubated colon cancer cells with two concentrations (2.4 and 12 μg/mL) of nickel nanowires that were 35 nm in diameter and exposed the cells and nanowires to an alternating magnetic field (0.5 mT and 1 Hz or 1 kHz) for 10 or 30 minutes. This low-power field exerted a force on the magnetic nanowires, causing a mechanical disturbance to the cells. Transmission electron microscopy images showed that the nanostructures were internalized into the cells within 1 hour of incubation. Cell viability studies showed that the magnetic field and the nanowires separately had minor deleterious effects on the cells; however, when combined, the magnetic field and nanowires caused the cell viability values to drop by up to 39%, depending on the strength of the magnetic field and the concentration of the nanowires. Cell membrane leakage experiments indicated membrane leakage of 20%, suggesting that cell death mechanisms induced by the nanowires and magnetic field involve some cell membrane rupture. Results suggest that magnetic nanowires can kill cancer cells. The proposed process requires simple and low-cost equipment with exposure to only very weak magnetic fields for short time periods. © 2015 Contreras et al.
dc.publisherDove Medical Press Ltd.
dc.relation.urlhttp://www.dovepress.com/non-chemotoxic-induction-of-cancer-cell-death-using-magnetic-nanowires-peer-reviewed-article-IJN
dc.relation.urlhttps://youtu.be/mYNeEfAOu0M
dc.rightsThis work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
dc.titleNon-chemotoxic induction of cancer cell death using magnetic nanowires
dc.typeArticle
dc.contributor.departmentImaging and Characterization Core Lab
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Lab
dc.identifier.journalInternational Journal of Nanomedicine
dc.identifier.pmcidPMC4370947
dc.eprint.versionPublisher's Version/PDF
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personSougrat, Rachid
kaust.personRavasi, Timothy
kaust.personKosel, Jürgen
kaust.personContreras, Maria F.
kaust.personZaher, Amir Omar
refterms.dateFOA2018-06-14T04:46:42Z


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