Non-chemotoxic induction of cancer cell death using magnetic nanowires
KAUST DepartmentAdvanced Nanofabrication, Imaging and Characterization Core Lab
Biological and Environmental Sciences and Engineering (BESE) Division
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Imaging and Characterization Core Lab
Integrative Systems Biology Lab
Sensing, Magnetism and Microsystems Lab
Permanent link to this recordhttp://hdl.handle.net/10754/346981
MetadataShow full item record
AbstractIn this paper, we show that magnetic nanowires with weak magnetic fields and low frequencies can induce cell death via a mechanism that does not involve heat production. We incubated colon cancer cells with two concentrations (2.4 and 12 μg/mL) of nickel nanowires that were 35 nm in diameter and exposed the cells and nanowires to an alternating magnetic field (0.5 mT and 1 Hz or 1 kHz) for 10 or 30 minutes. This low-power field exerted a force on the magnetic nanowires, causing a mechanical disturbance to the cells. Transmission electron microscopy images showed that the nanostructures were internalized into the cells within 1 hour of incubation. Cell viability studies showed that the magnetic field and the nanowires separately had minor deleterious effects on the cells; however, when combined, the magnetic field and nanowires caused the cell viability values to drop by up to 39%, depending on the strength of the magnetic field and the concentration of the nanowires. Cell membrane leakage experiments indicated membrane leakage of 20%, suggesting that cell death mechanisms induced by the nanowires and magnetic field involve some cell membrane rupture. Results suggest that magnetic nanowires can kill cancer cells. The proposed process requires simple and low-cost equipment with exposure to only very weak magnetic fields for short time periods. © 2015 Contreras et al.
CitationNon-chemotoxic induction of cancer cell death using magnetic nanowires 2015:2141 International Journal of Nanomedicine
PublisherInforma UK Limited
PubMed Central IDPMC4370947
CollectionsArticles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Imaging and Characterization Core Lab; Integrative Systems Biology Lab; Electrical and Computer Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division
- Cytotoxicity and intracellular dissolution of nickel nanowires.
- Authors: Perez JE, Contreras MF, Vilanova E, Felix LP, Margineanu MB, Luongo G, Porter AE, Dunlop IE, Ravasi T, Kosel J
- Issue date: 2016 Sep
- Functionalized magnetic nanowires for chemical and magneto-mechanical induction of cancer cell death.
- Authors: Martínez-Banderas AI, Aires A, Teran FJ, Perez JE, Cadenas JF, Alsharif N, Ravasi T, Cortajarena AL, Kosel J
- Issue date: 2016 Oct 24
- Magnetic and conductive magnetite nanowires by DNA-templating.
- Authors: Mohamed HD, Watson SM, Horrocks BR, Houlton A
- Issue date: 2012 Sep 28
- Thermal analysis of magnetic nanoparticle in alternating magnetic field on human HCT-116 colon cancer cell line.
- Authors: Attar MM, Amanpour S, Haghpanahi M, Haddadi M, Rezaei G, Muhammadnejad S, HajiAkhoundzadeh M, Barati T, Sadeghi F, Javadi S
- Issue date: 2016 Dec
- pH-dependent toxicity of high aspect ratio ZnO nanowires in macrophages due to intracellular dissolution.
- Authors: Müller KH, Kulkarni J, Motskin M, Goode A, Winship P, Skepper JN, Ryan MP, Porter AE
- Issue date: 2010 Nov 23