Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures
Pochapsky, Susan Sondej
Pochapsky, Thomas C.
KAUST DepartmentAnalytical Chemistry Core Lab
Imaging and Characterization Core Lab
Material Science and Engineering Program
Nanofabrication Core Lab
Physical Science and Engineering (PSE) Division
Online Publication Date2015-02-19
Print Publication Date2015-12
Permanent link to this recordhttp://hdl.handle.net/10754/346796
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AbstractWhile used extensively by nature to control the geometry of protein structures, and dynamics of proteins, such as self-organization, hydration forces and ionic interactions received less attention for controlling the behaviour of small molecules. Here we describe the synthesis and characterization of a novel zwitterionic metallopeptide consisting of a cationic core and three distal anionic groups linked by self-assembling peptide motifs. 2D NMR spectra, total correlated spectroscopy and nuclear Overhauser effect spectroscopy, show that the molecule exhibits a three-fold rotational symmetry and adopts a folded conformation in dimethyl sulfoxide due to Coulombic forces. When hydrated in water, the molecule unfolds to act as a self-assembling building block of supramolecular nanostructures. By combining ionic interactions with the unique geometry from metal complex and hydrophobic interactions from simple peptides, we demonstrate a new and effective way to design molecules for smart materials through mimicking a sophisticated biofunctional system using a conformational switch.
CitationUnfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures 2015, 6:6165 Nature Communications
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