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dc.contributor.authorRuocco, G.
dc.contributor.authorFratalocchi, Andrea
dc.date.accessioned2014-12-10T06:33:54Z
dc.date.available2014-12-10T06:33:54Z
dc.date.issued2014-11-18
dc.identifier.citationPeriod doubling induced by thermal noise amplification in genetic circuits 2014, 4:7088 Scientific Reports
dc.identifier.issn2045-2322
dc.identifier.pmid25404210
dc.identifier.doi10.1038/srep07088
dc.identifier.urihttp://hdl.handle.net/10754/337009
dc.description.abstractRhythms of life are dictated by oscillations, which take place in a wide rage of biological scales. In bacteria, for example, oscillations have been proven to control many fundamental processes, ranging from gene expression to cell divisions. In genetic circuits, oscillations originate from elemental block such as autorepressors and toggle switches, which produce robust and noise-free cycles with well defined frequency. In some circumstances, the oscillation period of biological functions may double, thus generating bistable behaviors whose ultimate origin is at the basis of intense investigations. Motivated by brain studies, we here study an “elemental” genetic circuit, where a simple nonlinear process interacts with a noisy environment. In the proposed system, nonlinearity naturally arises from the mechanism of cooperative stability, which regulates the concentration of a protein produced during a transcription process. In this elemental model, bistability results from the coherent amplification of environmental fluctuations due to a stochastic resonance of nonlinear origin. This suggests that the period doubling observed in many biological functions might result from the intrinsic interplay between nonlinearity and thermal noise.
dc.description.sponsorshipA. Fratalocchi acknowledges funding from KAUST (Award No. CRG-1-2012- FRA-005). For parallel computing, this research used the resources of the Primalight group at KAUST University.
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.urlhttp://www.nature.com/doifinder/10.1038/srep07088
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
dc.subjectBiophysics
dc.subjectPhysics
dc.titlePeriod doubling induced by thermal noise amplification in genetic circuits
dc.typeArticle
dc.contributor.departmentPRIMALIGHT Research Group
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.identifier.journalScientific Reports
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionSapienza University of Rome, Department of Physics, Piazzale Aldo Moro 5, 00185 Rome, Italy
dc.contributor.institutionCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome, Italy
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personFratalocchi, Andrea
kaust.personRuocco, Giancarlo
refterms.dateFOA2018-06-13T12:42:53Z


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