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dc.contributor.advisorKhashab, Niveen M.
dc.contributor.authorLi, Wengang
dc.date.accessioned2014-11-19T11:51:21Z
dc.date.available2015-12-01T00:00:00Z
dc.date.issued2014-09
dc.identifier.citationLi, W. (2014). Stimuli-Responsive Liposomes for Controlled Drug Delivery. KAUST Research Repository. https://doi.org/10.25781/KAUST-AR5XB
dc.identifier.doi10.25781/KAUST-AR5XB
dc.identifier.urihttp://hdl.handle.net/10754/335801
dc.description.abstractLiposomes are promising drug delivery vesicles due to their biodegradibility, large volume and biocompatibility towards both hydrophilic and hydrophobic drugs. They suffer, however, from poor stability which limits their use in controlled delivery applications. Herein, a novel method was devised for modification of liposomes with small molecules, polymers or nanoparticles to afford stimuli responsive systems that release on demand and stay relatively stable in the absence of the trigger.. This dissertation discusses thermosensitive, pH sensitive, light sensitive and magnetically triggered liposomes that have been prepared for controlled drug delivery application. RAFT polymerization was utilized for the preparation of thermosensitive liposomes (Cholesterol-PNIPAm) and acid-labile liposomes (DOPE-PAA). With low Mw Cholesterol-PNIPAm, the thermosensitive liposomes proved to be effective for controlled release and decreased the cytotoxicity of PNIPAm by eliciting the polymer doses. By crosslinking the DOPE-PAA on liposome surface with acid-labile diamine linkers, DOPE-PAA liposomes were verified to be sensitive at low pH. The effects of polymer structures (linear or hyperbranched) have also been studied for the stability and release properties of liposomes. Finally, a dual-responsive Au@SPIO embedded liposome hybrid (ALHs) was prepared with light-induced “on-and-off” function by photo-thermal process (visible light) and instant release properties triggered by alternating magnetic field, respectively. The ALH system would be further applied into the cellular imaging field as MRI contrast agent.
dc.language.isoen
dc.subjectLiposomes
dc.subjectdrug delivery
dc.subjectstimuli responsive
dc.subjectlipid polymer
dc.titleStimuli-Responsive Liposomes for Controlled Drug Delivery
dc.typeDissertation
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.rights.embargodate2015-12-01
thesis.degree.grantorKing Abdullah University of Science and Technology
dc.contributor.committeememberTakanabe, Kazuhiro
dc.contributor.committeememberHan, Yu
dc.contributor.committeememberWang, Peng
thesis.degree.disciplineChemical Science
thesis.degree.nameDoctor of Philosophy
dc.rights.accessrightsAt the time of archiving, the student author of this dissertation opted to temporarily restrict access to it. The full text of this dissertation became available to the public after the expiration of the embargo on 2015-12-01.
refterms.dateFOA2015-12-01T00:00:00Z


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